Molecular dynamics, viscoelastic properties and physical stability studies of a new amorphous dihydropyridine derivative with T-type calcium channel blocking activity.

Calcium Channel Blockers / chemistry Calcium Channels, T-Type Dihydropyridines / chemistry Drug Stability Elasticity Molecular Dynamics Simulation Viscosity
Amorphous APIs BDS Calcium channel blocker Dihydropyridine Melt viscosity Molecular dynamics Physical stability

Journal

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982

Informations de publication

Date de publication:
01 Jan 2020
Historique:
received: 24 04 2019
revised: 21 07 2019
accepted: 18 09 2019
pubmed: 22 10 2019
medline: 17 4 2020
entrez: 22 10 2019
Statut: ppublish

Résumé

One of the greatest problems of pre-clinical development of new chemical entities is their poor aqueous solubility. Herein, we focus our attention on MD20 - a novel calcium channel blocker that selectively blocks T-type calcium channel (Ca

Identifiants

DOI: 10.1016/j.ejps.2019.105083 PMID: 31634557
pubmed: 31634557
pii: S0928-0987(19)30356-2
doi: 10.1016/j.ejps.2019.105083
pii:
doi:

Substances chimiques

Calcium Channel Blockers 0
Calcium Channels, T-Type 0
Dihydropyridines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105083

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Justyna Knapik-Kowalczuk (J)

Faculty of Science and Technology, Institute of Physics, University of Silesia, SMCEBI, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland. Electronic address: justyna.knapik-kowalczuk@us.edu.pl.

Miyase Gözde Gündüz (MG)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey.

Krzysztof Chmiel (K)

Faculty of Science and Technology, Institute of Physics, University of Silesia, SMCEBI, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.

Karolina Jurkiewicz (K)

Faculty of Science and Technology, Institute of Physics, University of Silesia, SMCEBI, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.

Mateusz Kurek (M)

Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland.

Lidia Tajber (L)

School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, College Green, Dublin 2, Ireland.

Renata Jachowicz (R)

Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland.

Marian Paluch (M)

Faculty of Science and Technology, Institute of Physics, University of Silesia, SMCEBI, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux calciques › Molecular dynamics, viscoelastic properties...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques de type T › Molecular dynamics, viscoelastic properties...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Dihydropyridines › Molecular dynamics, viscoelastic properties...
questionsmedicales.fr › Techniques d'investigation › Stabilité de médicament › Molecular dynamics, viscoelastic properties...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Élasticité › Molecular dynamics, viscoelastic properties...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Molecular dynamics, viscoelastic properties...
questionsmedicales.fr › Phénomènes chimiques › Viscosité › Molecular dynamics, viscoelastic properties...