The Fragment-Based Development of a Benzofuran Hit as a New Class of
Benzofurans
/ chemical synthesis
Binding Sites
Crystallography, X-Ray
Drug Discovery
Enzyme Inhibitors
/ chemical synthesis
Escherichia coli
/ drug effects
Escherichia coli Proteins
/ antagonists & inhibitors
Models, Molecular
Molecular Structure
Protein Conformation
Protein Disulfide-Isomerases
/ antagonists & inhibitors
Small Molecule Libraries
/ chemical synthesis
DsbA inhibition
Escherichia coli
antibiotic resistance
bacterial virulence
benzofuran
disulfide bond
fragment-based drug discovery
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
18 Oct 2019
18 Oct 2019
Historique:
received:
09
09
2019
revised:
13
10
2019
accepted:
15
10
2019
entrez:
23
10
2019
pubmed:
23
10
2019
medline:
12
3
2020
Statut:
epublish
Résumé
A fragment-based drug discovery approach was taken to target the thiol-disulfide oxidoreductase enzyme DsbA from
Identifiants
pubmed: 31635355
pii: molecules24203756
doi: 10.3390/molecules24203756
pmc: PMC6832960
pii:
doi:
Substances chimiques
Benzofurans
0
Enzyme Inhibitors
0
Escherichia coli Proteins
0
Small Molecule Libraries
0
Protein Disulfide-Isomerases
EC 5.3.4.1
dsbA protein, E coli
EC 5.3.4.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Health and Medical Research Council
ID : 1099151
Organisme : National Health and Medical Research Council
ID : 1144046
Organisme : National Health and Medical Research Council
ID : FT130100580
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