Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts.

Animals Dantrolene / pharmacology Heart Failure / drug therapy Mice Muscle Relaxants, Central / pharmacology Pressure Protective Agents / pharmacology Ryanodine Receptor Calcium Release Channel / metabolism Tachycardia, Ventricular / drug therapy
Calcium Calmodulin Heart failure Ryanodine receptor Sarcoplasmic reticulum Ventricular tachycardia

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
01 01 2020
Historique:
received: 20 09 2019
accepted: 08 10 2019
pubmed: 23 10 2019
medline: 7 7 2020
entrez: 23 10 2019
Statut: ppublish

Résumé

Aberrant Ca

Identifiants

DOI: 10.1016/j.bbrc.2019.10.071 PMID: 31635807
pubmed: 31635807
pii: S0006-291X(19)31960-6
doi: 10.1016/j.bbrc.2019.10.071
pii:
doi:

Substances chimiques

Muscle Relaxants, Central 0
Protective Agents 0
Ryanodine Receptor Calcium Release Channel 0
Dantrolene F64QU97QCR

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

57-63

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Toshiro Kajii (T)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Shigeki Kobayashi (S)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Sho Shiba (S)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Shohei Fujii (S)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Masaki Tamitani (M)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Michiaki Kohno (M)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Yoshihide Nakamura (Y)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Takuma Nanno (T)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Takayoshi Kato (T)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Shinichi Okuda (S)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Hitoshi Uchinoumi (H)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Tetsuro Oda (T)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Takeshi Yamamoto (T)

Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Masafumi Yano (M)

Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan. Electronic address: yanoma@yamaguchi-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dantrolene prevents ventricular tachycardia by...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Imidazolidines › Hydantoïnes › Dantrolène › Dantrolene prevents ventricular tachycardia by...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Défaillance cardiaque › Dantrolene prevents ventricular tachycardia by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dantrolene prevents ventricular tachycardia by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Myorelaxants à action centrale › Dantrolene prevents ventricular tachycardia by...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Pression › Dantrolene prevents ventricular tachycardia by...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Dantrolene prevents ventricular tachycardia by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canal de libération du calcium du récepteur à la ryanodine › Dantrolene prevents ventricular tachycardia by...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Tachycardie › Tachycardie ventriculaire › Dantrolene prevents ventricular tachycardia by...