Associations between patient, treatment, or wound-level factors and venous leg ulcer healing: Wound characteristics are the key factors in determining healing outcomes.
Aged
Aged, 80 and over
Ankle Brachial Index
Anti-Inflammatory Agents, Non-Steroidal
/ therapeutic use
Body Mass Index
Compression Bandages
Exudates and Transudates
Female
Humans
Leg
/ pathology
Logistic Models
Male
Middle Aged
Odds Ratio
Organ Size
Prognosis
Sex Factors
Time Factors
Treatment Adherence and Compliance
Varicose Ulcer
/ pathology
Wound Healing
Journal
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
ISSN: 1524-475X
Titre abrégé: Wound Repair Regen
Pays: United States
ID NLM: 9310939
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
11
07
2019
revised:
10
09
2019
accepted:
07
10
2019
pubmed:
24
10
2019
medline:
29
6
2021
entrez:
24
10
2019
Statut:
ppublish
Résumé
Chronic venous leg ulcers are challenging to heal and often recur. This has a significant impact on older individual health and is a financial burden on health care resources. This study aimed to identify factors associated with the healing of venous leg ulcers via secondary examination of data from a previously published prospective randomized controlled trial of elastic and inelastic compression systems. The data from the 45 patients who finished the trial was reanalyzed for a hypothesis generating study. Larger ulcers, higher exudate levels, larger calf circumferences, and longer ulcer duration at baseline were associated with lack of healing at 12 weeks. There was some evidence that NSAID use was associated with an increased likelihood of nonhealing (unadjusted OR for healing, 0.13, 95% CI (0.02, 0.70)). There was no evidence that other variables, including gender and BMI, were associated with healing. The key risk factors for wound healing are largely wound based or inherent to wound development, as these were found to be the factors with the strongest associations in the analysis. Future research should address how and why these factors are associated with wound healing over a longer time frame and explore how NSAIDs may affect wound healing outcomes.
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
211-218Informations de copyright
© 2019 by the Wound Healing Society.
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