Drug Leads Derived from Japanese Marine Organisms.

3T3-L1 Cells Animals Aquatic Organisms Biological Products / isolation & purification Cyanobacteria Ethers, Cyclic Japan Macrolides Mice Okadaic Acid Polyketides / isolation & purification Pyrones / isolation & purification
Natural products halichondrin B halichrome A metagenomic analysis okadaic acid symbiotic bacteria terpenoids yoshinone A

Journal

Current medicinal chemistry
ISSN: 1875-533X
Titre abrégé: Curr Med Chem
Pays: United Arab Emirates
ID NLM: 9440157

Informations de publication

Date de publication:
2021
Historique:
received: 29 05 2019
revised: 05 08 2019
accepted: 12 08 2019
pubmed: 24 10 2019
medline: 9 2 2021
entrez: 24 10 2019
Statut: ppublish

Résumé

Many natural products with extraordinary chemical structures and brilliant biological activities have been obtained from marine organisms. We have investigated such fascinating bioactive molecules, exemplified by the potent marine toxin palytoxin and the antitumor molecule halichondrin B, which has been developed as the anticancer drug Halaven®, to explore novel frontiers in organic chemistry and bioscience. Working within the traditional discipline, we have sought to acquire a deeper understanding of biological phenomena. We introduce here our major work along with up-todate topics. We isolated yoshinone A from marine cyanobacteria and completed a gram-scale synthesis. Yoshinone A is a novel polyketide that inhibited the differentiation of 3T3-L1 cells into adipocytes without significant cytotoxicity. The detailed mechanisms of action will be elucidated via further experiments in vitro and in vivo. In this study, we explore the true producers of okadaic acid and halichondrin B by immunostaining of Halichondria okadai with an antibody that was prepared using these natural products as an antigen. We will analyze isolated symbionts and reveal biosynthetic pathways.

Identifiants

DOI: 10.2174/0929867326666191022125851 PMID: 31642409
pubmed: 31642409
pii: CMC-EPUB-101761
doi: 10.2174/0929867326666191022125851
doi:

Substances chimiques

Biological Products 0
Ethers, Cyclic 0
Macrolides 0
Polyketides 0
Pyrones 0
yoshinone A 0
Okadaic Acid 1W21G5Q4N2
halichondrin B 269R6PFM59

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

196-210

Subventions

Organisme : Grant-in-Aid for Challenging Exploratory Research
ID : 20651058
Organisme : Grant-in-Aid for Scientific Research
ID : 21221009, 21241054, 25242069

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

Daisuke Uemura (D)

Institute for Advanced Research (Emeritus), Nagoya University, Nagoya, Japan.

Yoshinori Kawazoe (Y)

Center for Education and Research in Agricultural Innovation, Faculty of Agriculture, Saga University, Karatsu, Japan.

Toshiyasu Inuzuka (T)

Life Science Research Center, Gifu University, Gifu, Japan.

Yuki Itakura (Y)

Department of Chemistry, Faculty of Science, Kanagawa University, Hiratsuka, Japan.

Chiari Kawamata (C)

Department of Chemistry, Faculty of Science, Kanagawa University, Hiratsuka, Japan.

Takahiro Abe (T)

Department of Chemistry, Faculty of Science, Kanagawa University, Hiratsuka, Japan.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Cellules Swiss 3T3 › Cellules 3T3-L1 › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Eucaryotes › Animaux › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Phénomènes biologiques › Phénomènes écologiques et environnementaux › Eaux salées › Eau de mer › Organismes aquatiques › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Bactéries à Gram négatif photosynthétiques › Cyanobactéries › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Éthers cycliques › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Régions géographiques › Iles › Japon › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines de la flore et de la faune marines › Acide okadaïque › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Drug Leads Derived from Japanese Marine Organisms.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrannes › Pyrones › Drug Leads Derived from Japanese Marine Organisms.