Serum elaidic acid concentration and risk of dementia: The Hisayama Study.

Aged Aged, 80 and over Alzheimer Disease / blood Dementia / blood Dementia, Vascular / blood Female Gas Chromatography-Mass Spectrometry Humans Incidence Japan / epidemiology Male Middle Aged Oleic Acids / blood Proportional Hazards Models Trans Fatty Acids / blood

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
26 11 2019
Historique:
received: 08 11 2018
accepted: 28 06 2019
pubmed: 28 10 2019
medline: 6 2 2020
entrez: 25 10 2019
Statut: ppublish

Résumé

The associations between trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. In total, 1,628 Japanese community residents aged 60 and older without dementia were followed prospectively from when they underwent a screening examination in 2002-2003 to November 2012 (median 10.3 years, interquartile range 7.2-10.4 years). Serum elaidic acid levels were measured using gas chromatography/mass spectrometry and divided into quartiles. The Cox proportional hazards model was used to estimate the hazard ratios for all-cause dementia, Alzheimer disease (AD), and vascular dementia by serum elaidic acid levels. During the follow-up, 377 participants developed some type of dementia (247 AD, 102 vascular dementia). Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia ( The findings suggest that higher serum elaidic acid is a possible risk factor for the development of all-cause dementia and AD in later life. Public health policy to reduce industrially produced trans fatty acids may assist in the primary prevention of dementia.

Identifiants

DOI: 10.1212/WNL.0000000000008464 PMID: 31645469
pubmed: 31645469
pii: WNL.0000000000008464
doi: 10.1212/WNL.0000000000008464
doi:

Substances chimiques

Oleic Acids 0
Trans Fatty Acids 0
elaidic acid 4837010H8C

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2053-e2064

Informations de copyright

© 2019 American Academy of Neurology.

Auteurs

Takanori Honda (T)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Tomoyuki Ohara (T)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Masakazu Shinohara (M)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Jun Hata (J)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Ryuji Toh (R)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Daigo Yoshida (D)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Mao Shibata (M)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Tatsuro Ishida (T)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Yoichiro Hirakawa (Y)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Yasuhiro Irino (Y)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Satoko Sakata (S)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Kazuhiro Uchida (K)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Takanari Kitazono (T)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Shigenobu Kanba (S)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Ken-Ichi Hirata (KI)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.

Toshiharu Ninomiya (T)

From the Departments of Epidemiology and Public Health (T.H., T.O., J.H., D.Y., M.Shibata, Y.H., S.S., T.N.), Neuropsychiatry (T.O., S.K.), Medicine and Clinical Science (J.H., Y.H., S.S., T.K.), and Psychosomatic Medicine (M.Shibata), and Center for Cohort Studies (J.H., M.Shibata, S.S., T.K., T.N.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; Divisions of Epidemiology (M.Shinohara), Evidence-Based Laboratory Medicine (R.T., Y.I.), and Cardiovascular Medicine (T.I., K.-I.H.), and Integrated Center for Mass Spectrometry (M.Shinohara., Y.I.), Kobe University Graduate School of Medicine, Hyogo; and Department of Health Promotion (K.U.), School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan. nino@eph.med.kyushu-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Démence vasculaire › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Chromatographie gazeuse-spectrométrie de masse › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Régions géographiques › Iles › Japon › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Acides oléiques › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Modèles des risques proportionnels › Serum elaidic acid concentration and risk of...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras trans › Serum elaidic acid concentration and risk of...