Simultaneous primary cancer occurrence of melanoma and pulmonary adenocarcinoma in leptomeningeal metastases: a case report.
Adenocarcinoma
Leptomeningeal metastasis
Melanoma
Simultaneous
Journal
BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800
Informations de publication
Date de publication:
23 Oct 2019
23 Oct 2019
Historique:
received:
12
03
2019
accepted:
20
09
2019
entrez:
25
10
2019
pubmed:
28
10
2019
medline:
27
2
2020
Statut:
epublish
Résumé
Leptomeningeal metastasis (LM) is a predominantly late stage, devastating complication of a variety of malignant solid tumors. Diagnosis relies predominantly on neurological, radiographic, and cerebrospinal fluid (CSF) assessments. Recently, liquid biopsy tests derived from CSF has shown to be a feasible, noninvasive promising approach to tumor molecular profiling for proper brain cancer diagnostic treatment, thereby providing an opportunity for CSF-based personalized medicine. However, LM is typically misleadingly assumed to originate from only one primary tumor type. In this case report, we provide first evidence of the co-occurrence of LM originating from more than one primary tumor types. Based on this patient case profile, the co-occurrence of LM from two or more primary tumor types should be accounted for when deriving diagnostic conclusions from liquid biopsy tests.
Sections du résumé
BACKGROUND
BACKGROUND
Leptomeningeal metastasis (LM) is a predominantly late stage, devastating complication of a variety of malignant solid tumors. Diagnosis relies predominantly on neurological, radiographic, and cerebrospinal fluid (CSF) assessments. Recently, liquid biopsy tests derived from CSF has shown to be a feasible, noninvasive promising approach to tumor molecular profiling for proper brain cancer diagnostic treatment, thereby providing an opportunity for CSF-based personalized medicine. However, LM is typically misleadingly assumed to originate from only one primary tumor type.
CASE PRESENTATION
METHODS
In this case report, we provide first evidence of the co-occurrence of LM originating from more than one primary tumor types.
DISCUSSION AND CONCLUSIONS
CONCLUSIONS
Based on this patient case profile, the co-occurrence of LM from two or more primary tumor types should be accounted for when deriving diagnostic conclusions from liquid biopsy tests.
Identifiants
pubmed: 31646997
doi: 10.1186/s12885-019-6183-2
pii: 10.1186/s12885-019-6183-2
pmc: PMC6813083
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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