Risk of cervical intraepithelial neoplasia grade 2 or worse after conization in relation to HPV vaccination status.
Adolescent
Adult
Conization
/ methods
Denmark
Female
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
/ therapeutic use
Humans
Middle Aged
Papillomavirus Infections
/ prevention & control
Proportional Hazards Models
Prospective Studies
Treatment Outcome
Uterine Cervical Neoplasms
/ surgery
Vaccination
/ statistics & numerical data
Young Adult
Uterine Cervical Dysplasia
/ surgery
HPV vaccination
cervical cancer
cervical neoplasia
conization
prospective cohort study
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
received:
11
01
2019
revised:
06
10
2019
accepted:
15
10
2019
pubmed:
28
10
2019
medline:
12
3
2021
entrez:
25
10
2019
Statut:
ppublish
Résumé
Human papillomavirus (HPV) is essential for developing cervical cancer and precancerous lesions. Currently, three vaccines are available, which are effective as prophylaxis against HPV infection, however, limited knowledge exists about the possible effect of vaccinating women treated with conization to prevent recurrence. The aim of our study was to examine the risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) after conization according to HPV vaccination status. Using Danish nationwide registries, we identified women diagnosed with CIN3 on the cone (2006-2012) and their HPV vaccination status. Vaccinees were defined as women vaccinated between 3 months before until 1 year after conization. The women were followed from 1 year after conization until diagnosis of CIN2+, conization, death, emigration or end of follow-up. Cox proportional hazard regression was used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of CIN2+ comparing vaccinees with nonvaccinees. The HR was adjusted for age, histology on cone, education, year of conization, repeat conizations and CIN2+ lesions between conization and start of follow-up. Altogether 17,128 women were included (2,074 vaccinees). There was a statistically nonsignificant lower risk of CIN2+ among vaccinees (HR
Substances chimiques
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
641-647Informations de copyright
© 2019 UICC.
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