Phagosome-endoplasmic reticulum contacts: Kissing and not running.
ORP1L-
VAP
cholesterol
endoplasmic reticulum
endosome
lysosome
macrophage
membrane contact
phagosome
phosphoinositide
Journal
Traffic (Copenhagen, Denmark)
ISSN: 1600-0854
Titre abrégé: Traffic
Pays: England
ID NLM: 100939340
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
03
09
2019
revised:
14
10
2019
accepted:
16
10
2019
pubmed:
28
10
2019
medline:
28
4
2021
entrez:
26
10
2019
Statut:
ppublish
Résumé
The role of the endoplasmic reticulum (ER) in phagocytosis has been the subject of debate for over a decade. Proteomic determinations and dynamic microscopy of live cells led to conflicting conclusions. Recent insights into the existence of a variety of membrane contact sites (MCS) may help reconcile the seemingly disparate views. Specifically, earlier results can be rationalized considering that the ER forms specialized MCS with nascent and maturing phagosomes, without undergoing fusion. The composition and function of documented ER-to-phagosome contact sites is described. In addition, we speculate about the possible existence of additional phagosomal contact sites, based on available knowledge of interactions between the ER and other endocytic compartments. The interaction between phagosomes and the ER has been the subject of debate. Earlier observations that led to the suggestion that the ER fuses with the phagosomal membrane can now be explained in the light of recent evidence that intimate contacts form between the two organelles.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
172-180Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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