Association between PHOX2B gene rs28647582 T>C polymorphism and Wilms tumor susceptibility.
PHOX2B
Wilms tumor
polymorphism
rs28647582
susceptibility
Journal
Bioscience reports
ISSN: 1573-4935
Titre abrégé: Biosci Rep
Pays: England
ID NLM: 8102797
Informations de publication
Date de publication:
30 10 2019
30 10 2019
Historique:
received:
22
07
2019
revised:
08
09
2019
accepted:
03
10
2019
entrez:
26
10
2019
pubmed:
28
10
2019
medline:
17
9
2020
Statut:
ppublish
Résumé
Wilms tumor is one of the most common pediatric solid tumors. The pair-like homeobox 2b (PHOX2B) gene is an important transcription factor that regulates cellular proliferation and differentiation in early life. The association between PHOX2B single nucleotide polymorphisms (SNPs) and Wilms tumor risk has not been investigated. Therefore, we conducted a case-control study involving 145 Wilms tumor patients and 531 controls to explore the association between the PHOX2B rs28647582 T>C polymorphism and Wilms tumor susceptibility. The association between the PHOX2B rs28647582 T>C polymorphism and Wilms tumor susceptibility was assessed by odds ratios (ORs) and 95% confidence intervals (CIs). Our results indicated that PHOX2B rs28647582 T>C polymorphism did not significantly alter Wilms tumor susceptibility. However, in the stratified analysis, we found that TC/CC genotypes significantly increased Wilms tumor risk among children older than 18 months (adjusted OR = 1.77, 95% CI = 1.07-2.95, P=0.027) and those with clinical stages III+IV (adjusted OR = 1.75, 95% CI = 1.09-2.82, P=0.022), when compared with those with TT genotype. Our study suggested that PHOX2B rs28647582 T>C was weakly associated with Wilms tumor susceptibility. Our conclusions need further validation with a larger sample size.
Identifiants
pubmed: 31652452
pii: 220823
doi: 10.1042/BSR20192529
pmc: PMC6822530
pii:
doi:
Substances chimiques
Homeodomain Proteins
0
NBPhox protein
0
Neoplasm Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019 The Author(s).
Références
Nat Genet. 2003 Apr;33(4):459-61
pubmed: 12640453
Biochem J. 2006 Apr 15;395(2):355-61
pubmed: 16402914
Mol Ther Nucleic Acids. 2018 Sep 7;12:854-860
pubmed: 30161024
Infect Genet Evol. 2016 Oct;44:495-500
pubmed: 27491457
Development. 2002 Nov;129(22):5241-53
pubmed: 12399315
Cancer Invest. 2017 Nov 26;35(10):633-638
pubmed: 29243987
Pediatr Blood Cancer. 2013 Jun;60(6):994-1000
pubmed: 23255438
Cell. 2006 Jul 14;126(1):37-47
pubmed: 16839875
Neuron. 1999 Apr;22(4):693-705
pubmed: 10230790
Exp Cell Res. 2008 Feb 15;314(4):707-19
pubmed: 18201699
Br J Cancer. 2000 Jul;83(2):177-83
pubmed: 10901367
EBioMedicine. 2018 Jul;33:88-93
pubmed: 29937070
PLoS One. 2014 Mar 20;9(3):e90091
pubmed: 24651702
J Clin Invest. 2012 Sep;122(9):3145-58
pubmed: 22922260
Nat Genet. 2018 Mar;50(3):338-343
pubmed: 29379198
Genome Med. 2015 Feb 02;7(1):11
pubmed: 25763109
J Comp Neurol. 2007 Aug 10;503(5):627-41
pubmed: 17559094
J Biol Chem. 2005 Nov 11;280(45):37439-48
pubmed: 16144830
Hum Genet. 2012 Jul;131(7):1235-44
pubmed: 22371296
Gut. 2003 Apr;52(4):563-7
pubmed: 12631670
J Pediatr Surg. 2009 Sep;44(9):1805-11
pubmed: 19735829
Nat Genet. 1996 Aug;13(4):461-3
pubmed: 8696342
BMC Biol. 2007 Oct 26;5:47
pubmed: 17963489
EBioMedicine. 2017 Feb;16:101-105
pubmed: 28161399
Hum Genet. 2003 Dec;114(1):22-6
pubmed: 14566559
J Neurosci. 2006 Oct 4;26(40):10305-14
pubmed: 17021186
PLoS One. 2010 Oct 01;5(10):null
pubmed: 20957039
Onco Targets Ther. 2017 Feb 23;10:1149-1154
pubmed: 28260929
Genes Dev. 2015 Mar 1;29(5):467-82
pubmed: 25737276
Am J Hum Genet. 2004 Oct;75(4):727-30
pubmed: 15338462
Am J Med Genet A. 2003 Dec 15;123A(3):267-78
pubmed: 14608649
Biochim Biophys Acta Mol Basis Dis. 2017 Jul;1863(7):1770-1777
pubmed: 28433712
Oncotarget. 2017 Apr 7;8(31):50665-50672
pubmed: 28881592
Curr Opin Pediatr. 2009 Jun;21(3):357-64
pubmed: 19417665
Curr Opin Genet Dev. 2017 Feb;42:81-90
pubmed: 28458126
Oncogene. 2008 Jan 17;27(4):469-76
pubmed: 17637745
Genes Chromosomes Cancer. 2012 Jul;51(7):644-53
pubmed: 22407497
Genomics. 1999 Jul 1;59(1):40-50
pubmed: 10395798
Zhonghua Er Ke Za Zhi. 2013 Apr;51(4):288-94
pubmed: 23927803
Nature. 1999 May 27;399(6734):366-70
pubmed: 10360575
Nat Commun. 2014 Aug 07;5:4398
pubmed: 25099282
Am J Hum Genet. 2004 Apr;74(4):761-4
pubmed: 15024693
Cancer Genet. 2012 Mar;205(3):80-93
pubmed: 22469507