The Role of Growth Hormone in Mesenchymal Stem Cell Commitment.
bone repair
cell differentiation
growth hormone
regenerative medicine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Oct 2019
23 Oct 2019
Historique:
received:
26
09
2019
revised:
18
10
2019
accepted:
21
10
2019
entrez:
27
10
2019
pubmed:
28
10
2019
medline:
4
3
2020
Statut:
epublish
Résumé
Growth hormone (GH) is best known for its prominent role in promoting prepubertal growth and in regulating body composition and metabolism during adulthood. In recent years, the possible role of GH in the modulation of mesenchymal stem cell (MSC) commitment has gained interest. MSCs, characterized by active self-renewal and differentiation potential, express GH receptors. In MSCs derived from different adult tissues, GH induces an inhibition of adipogenic differentiation and favors MSC differentiation towards osteogenesis. This activity of GH indicates that regulation of body composition by GH has already started in the tissue progenitor cells. These findings have fostered research on possible uses of MSCs treated with GH in those pathologies, where a lack of or delays in bone repair occur. After an overview of GH activities, this review will focus on the research that has characterized GH's effects on MSCs and on preliminary studies on the possible application of GH in bone regenerative medicine.
Identifiants
pubmed: 31652811
pii: ijms20215264
doi: 10.3390/ijms20215264
pmc: PMC6862273
pii:
doi:
Substances chimiques
Growth Hormone
9002-72-6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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