Promising Prognosis Marker Candidates on the Status of Epithelial-Mesenchymal Transition and Glioma Stem Cells in Glioblastoma.
Adult
Biomarkers, Tumor
/ genetics
Databases, Genetic
Epithelial-Mesenchymal Transition
/ genetics
Female
Gene Expression
/ genetics
Gene Expression Regulation, Neoplastic
/ genetics
Glioblastoma
/ genetics
Glioma
/ metabolism
Humans
Kaplan-Meier Estimate
Male
Neoplastic Stem Cells
/ pathology
Prognosis
Proportional Hazards Models
Transcriptome
/ genetics
epithelial-mesenchymal transition
glioblastoma
glioma stem cell
multivariable analysis
prognosis prediction
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 10 2019
24 10 2019
Historique:
received:
29
09
2019
revised:
21
10
2019
accepted:
22
10
2019
entrez:
27
10
2019
pubmed:
28
10
2019
medline:
15
8
2020
Statut:
epublish
Résumé
Multivariable analyses of global expression profiling are valid indicators of the prognosis of various diseases including brain cancers. To identify the candidates for markers of prognosis of glioblastoma, we performed multivariable analyses on the status of epithelial (EPI)-mesenchymal (MES) transition (EMT), glioma (GLI) stem cells (GSCs), molecular target therapy (MTT), and potential glioma biomarkers (PGBs) using the expression data and clinical information from patients. Random forest survival and Cox proportional hazards regression analyses indicated significant variable values for
Identifiants
pubmed: 31653034
pii: cells8111312
doi: 10.3390/cells8111312
pmc: PMC6912254
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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