Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit.

Acetaminophen / pharmacology Analgesics / pharmacology Analgesics, Opioid / pharmacology Anti-Inflammatory Agents, Non-Steroidal / pharmacology Clonidine / pharmacology Combined Modality Therapy Dexmedetomidine / pharmacology Fentanyl / pharmacology Humans Hypnotics and Sedatives / pharmacology Infant, Newborn Intensive Care Units, Neonatal Midazolam / pharmacology Morphine / pharmacology Pain / drug therapy Pain Management / methods Pharmacogenomic Variants Precision Medicine Remifentanil / pharmacology
Analgesia Neonatal Pain Pharmacology Sedation

Journal

Clinics in perinatology
ISSN: 1557-9840
Titre abrégé: Clin Perinatol
Pays: United States
ID NLM: 7501306

Informations de publication

Date de publication:
12 2019
Historique:
entrez: 27 10 2019
pubmed: 28 10 2019
medline: 21 7 2020
Statut: ppublish

Résumé

In this review of analgesic and sedation medication in neonates, important classes of old and newer medications commonly used in the neonatal intensive care unit setting are discussed. In addition to drug metabolism, efficacy, and safety for individual drugs, new insights into multimodal analgesic approaches suggest ways in which multiple analgesic drug classes can be combined to maximize efficacy and minimize toxicity. Opiate pharmacogenetics and the potential for a precision therapeutics approach is explored, with a final description of gaps in knowledge and a call for future research of pain and sedation control in the neonatal population.

Identifiants

DOI: 10.1016/j.clp.2019.08.004 PMID: 31653302
pubmed: 31653302
pii: S0095-5108(19)30092-2
doi: 10.1016/j.clp.2019.08.004
pii:
doi:

Substances chimiques

Analgesics 0
Analgesics, Opioid 0
Anti-Inflammatory Agents, Non-Steroidal 0
Hypnotics and Sedatives 0
Acetaminophen 362O9ITL9D
Dexmedetomidine 67VB76HONO
Morphine 76I7G6D29C
Clonidine MN3L5RMN02
Remifentanil P10582JYYK
Midazolam R60L0SM5BC
Fentanyl UF599785JZ

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

673-692

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Jamesia Donato (J)

Department of Pediatrics, Division of Neonatology, UMKC School of Medicine, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA.

Karishma Rao (K)

Department of Pediatrics, Division of Neonatology, UMKC School of Medicine, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA.

Tamorah Lewis (T)

Department of Pediatrics, Division of Neonatology, UMKC School of Medicine, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Division of Pediatric Clinical Pharmacology, UMKC School of Medicine, Children's Mercy Hospital, Kansas City, MO, USA. Electronic address: trlewis@cmh.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › Acétanilides › Acétaminophène › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antirhumatismaux › Anti-inflammatoires non stéroïdiens › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Imidazolines › Clonidine › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Thérapeutique › Association thérapeutique › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Dexmédétomidine › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Fentanyl › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Hypnotiques et sédatifs › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Unités hospitalières › Unités de soins intensifs › Unités de soins intensifs pédiatriques › Unités de soins intensifs néonatals › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Midazolam › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Morphinanes › Dérivés de la morphine › Morphine › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Prise en charge de la maladie › Gestion de la douleur › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Variants pharmacogénomiques › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Pharmacology of Common Analgesic and Sedative...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Rémifentanil › Pharmacology of Common Analgesic and Sedative...