Spring peaks and autumn troughs identified in peripheral inflammatory markers during the peripartum period.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
25 10 2019
25 10 2019
Historique:
received:
13
02
2019
accepted:
01
10
2019
entrez:
27
10
2019
pubmed:
28
10
2019
medline:
30
10
2020
Statut:
epublish
Résumé
Seasonal variations have recently been described in biomarkers, cell types, and gene expression associated with the immune system, but so far no studies have been conducted among women in the peripartum period. It is of note that pregnancy complications and outcomes, as well as autoimmune diseases, have also been reported to exhibit seasonal fluctuations. We report here a clear-cut seasonal pattern of 23 inflammatory markers, analysed using proximity-extension assay technology, in pregnant women. The inflammatory markers generally peaked in the spring and had a trough in the autumn. During the postpartum period we found seasonality in one inflammatory marker, namely monocyte chemotactic protein 4 (MCP-4). Our findings suggest that seasonal variations in peripheral inflammatory markers are only observed during pregnancy. The results of this study could be valuable to professionals working within the field of immunology-related areas, and provide insight for the understanding of obstetric complications.
Identifiants
pubmed: 31653981
doi: 10.1038/s41598-019-51527-9
pii: 10.1038/s41598-019-51527-9
pmc: PMC6814733
doi:
Substances chimiques
Biomarkers
0
CSF1 protein, human
0
Inflammation Mediators
0
Vascular Endothelial Growth Factor A
0
Macrophage Colony-Stimulating Factor
81627-83-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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