Investigation of metabolite-protein interactions by transient absorption spectroscopy and in silico methods.
Anti-Inflammatory Agents, Non-Steroidal
/ chemistry
Antipsychotic Agents
/ chemistry
Binding Sites
Carbazoles
/ chemistry
Chlorpromazine
/ analogs & derivatives
Drug Interactions
Humans
Hydrogen Bonding
Inactivation, Metabolic
Methylation
Molecular Docking Simulation
Molecular Dynamics Simulation
Protein Binding
/ drug effects
Serum Albumin, Human
/ chemistry
Spectrophotometry, Ultraviolet
Stereoisomerism
Carprofen
Docking
Human serum albumin
Laser flash photolysis
Molecular dynamics simulations
Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533
Informations de publication
Date de publication:
05 Feb 2020
05 Feb 2020
Historique:
received:
25
06
2019
revised:
23
09
2019
accepted:
10
10
2019
pubmed:
28
10
2019
medline:
23
6
2020
entrez:
27
10
2019
Statut:
ppublish
Résumé
Transient absorption spectroscopy in combination with in silico methods has been employed to study the interactions between human serum albumin (HSA) and the anti-psychotic agent chlorpromazine (CPZ) as well as its two demethylated metabolites (MCPZ and DCPZ). Thus, solutions containing CPZ, MCPZ or DCPZ and HSA (molar ligand:protein ratios between 1:0 and 1:3) were submitted to laser flash photolysis and the ΔA
Identifiants
pubmed: 31654902
pii: S1386-1425(19)31042-X
doi: 10.1016/j.saa.2019.117652
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Antipsychotic Agents
0
Carbazoles
0
methochlorpromazine
19077-31-7
carprofen
FFL0D546HO
Chlorpromazine
U42B7VYA4P
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117652Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.