Endothelin signalling mediates experience-dependent myelination in the CNS.
endothelin
mouse
myelination
neuroscience
oligodendrocytes
rat
zebrafish
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
28 10 2019
28 10 2019
Historique:
received:
19
06
2019
accepted:
26
10
2019
pubmed:
29
10
2019
medline:
12
3
2020
entrez:
29
10
2019
Statut:
epublish
Résumé
Experience and changes in neuronal activity can alter CNS myelination, but the signalling pathways responsible remain poorly understood. Here we define a pathway in which endothelin, signalling through the G protein-coupled receptor endothelin receptor B and PKC epsilon, regulates the number of myelin sheaths formed by individual oligodendrocytes in mouse and zebrafish. We show that this phenotype is also observed in the prefrontal cortex of mice following social isolation, and is associated with reduced expression of vascular endothelin. Additionally, we show that increasing endothelin signalling rescues this myelination defect caused by social isolation. Together, these results indicate that the vasculature responds to changes in neuronal activity associated with experience by regulating endothelin levels, which in turn affect the myelinating capacity of oligodendrocytes. This pathway may be employed to couple the metabolic support function of myelin to activity-dependent demand and also represents a novel mechanism for adaptive myelination.
Identifiants
pubmed: 31657718
doi: 10.7554/eLife.49493
pii: 49493
pmc: PMC6831104
doi:
pii:
Substances chimiques
EDNRB protein, mouse
0
Endothelins
0
Receptor, Endothelin B
0
Protein Kinase C-epsilon
EC 2.7.11.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : G0601744
Pays : United Kingdom
Organisme : Multiple Sclerosis Society
ID : 950
Pays : United Kingdom
Organisme : Wellcome
ID : Senior Investigator Award
Pays : International
Organisme : Wellcome
ID : 102836/Z/13/Z
Pays : International
Informations de copyright
© 2019, Swire et al.
Déclaration de conflit d'intérêts
MS, YK, DW, DL, Cf No competing interests declared
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