A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable.


Journal

International journal of stroke : official journal of the International Stroke Society
ISSN: 1747-4949
Titre abrégé: Int J Stroke
Pays: United States
ID NLM: 101274068

Informations de publication

Date de publication:
10 2019
Historique:
entrez: 30 10 2019
pubmed: 30 10 2019
medline: 4 4 2020
Statut: ppublish

Résumé

A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.

Identifiants

pubmed: 31658893
doi: 10.1177/1747493019879657
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

792-802

Subventions

Organisme : CIHR
Pays : Canada

Auteurs

Julie Bernhardt (J)

Stroke Theme and NHRMC CRE in Stroke Rehabilitation and Brain Recovery, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.

Kathryn S Hayward (KS)

Stroke Theme and NHRMC CRE in Stroke Rehabilitation and Brain Recovery, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.

Numa Dancause (N)

Département de Neurosciences, Université de Montréal, Montréal, Québec, Canada.

Natasha A Lannin (NA)

Department of Clinical Neuroscience, Central Clinical School, Monash University; Alfred Health, Melbourne, Australia.

Nick S Ward (NS)

Department of Clinical and Motor Neuroscience, UCL Queen Square Institute of Neurology, London, UK.

Randolph J Nudo (RJ)

Department of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City, KS, USA.

Amanda Farrin (A)

Leeds Institute of Clinical Trial Research, University of Leeds, Leeds, UK.

Leonid Churilov (L)

Melbourne Medical School, University of Melbourne, Melbourne, Australia.

Lara A Boyd (LA)

Department of Physical Therapy & Centre for Brain Health, University of British Columbia, Vancouver, Canada.

Theresa A Jones (TA)

Psychology Department and Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA.

S Thomas Carmichael (ST)

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Dale Corbett (D)

Cellular & Molecular Medicine and Canadian Partnership for Stroke Recovery, University of Ottawa, Ottawa, Canada.

Steven C Cramer (SC)

Department of Neurology, David Geffen School of Medicine at UCLA; California Rehabilitation Institute, Los Angeles, CA, USA.

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