Cerebellar climbing fibers encode expected reward size.
cerebellum
complex spikes
neuroscience
reinforcement learning
reward prediction
smooth pursuit
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
29 10 2019
29 10 2019
Historique:
received:
14
03
2019
accepted:
24
10
2019
pubmed:
30
10
2019
medline:
21
3
2020
entrez:
30
10
2019
Statut:
epublish
Résumé
Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward. To study how rewarding events are encoded, we recorded the activity of climbing fibers when monkeys were engaged in an eye movement task. At the beginning of each trial, the monkeys were cued to the size of the reward that would be delivered upon successful completion of the trial. Climbing fiber activity increased when the monkeys were presented with a cue indicating a large reward, but not a small reward. Reward size did not modulate activity at reward delivery or during eye movements. Comparison between climbing fiber and simple spike activity indicated different interactions for coding of movement and reward. These results indicate that climbing fibers encode the expected reward size and suggest a general role of the cerebellum in associative learning beyond error correction.
Identifiants
pubmed: 31661073
doi: 10.7554/eLife.46870
pii: 46870
pmc: PMC6844644
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : H2020 European Research Council
ID : imove 755745
Pays : International
Organisme : Human Frontier Science Program
ID : CDA 00056
Pays : International
Organisme : Israel Science Foundation
ID : 38017
Pays : International
Informations de copyright
© 2019, Larry et al.
Déclaration de conflit d'intérêts
NL, MY, AL, MJ No competing interests declared
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