White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood.
cingulum
general psychopathology
myelin
structural connectivity
uncinate fasciculus
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 02 2020
15 02 2020
Historique:
received:
23
07
2019
revised:
30
09
2019
accepted:
14
10
2019
pubmed:
30
10
2019
medline:
23
7
2021
entrez:
30
10
2019
Statut:
ppublish
Résumé
Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psychiatric vulnerability is linked to aberrant developmental myelination trajectories. We assessed a marker of myelin maturation, using magnetisation transfer (MT) imaging, in 10 major white matter tracts. We then investigated its relationship to the expression of a general psychopathology "p-factor" in a longitudinal analysis of 293 healthy participants between the ages of 14 and 24. We observed significant longitudinal MT increase across the full age spectrum in anterior thalamic radiation, hippocampal cingulum, dorsal cingulum and superior longitudinal fasciculus. MT increase in the inferior fronto-occipital fasciculus, inferior longitudinal fasciculus and uncinate fasciculus was pronounced in younger participants but levelled off during the transition into young adulthood. Crucially, longitudinal MT increase in dorsal cingulum and uncinate fasciculus decelerated as a function of mean p-factor scores over the study period. This suggests that an increased expression of psychopathology is closely linked to lower rates of myelin maturation in selective brain tracts over time. Impaired myelin growth in limbic association fibres may serve as a neural marker for emerging mental illness during the course of adolescence and early adulthood.
Identifiants
pubmed: 31661180
doi: 10.1002/hbm.24842
pmc: PMC7268015
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
827-839Subventions
Organisme : Wellcome Trust
ID : 095844/7/11/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098362/Z/12/Z
Pays : United Kingdom
Organisme : Department of Health
ID : NF-SI-0514-10157
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_G0802534
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
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