Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.

Adolescent Age Factors Animals Child Child, Preschool Female Humans Infant Leukemia, Myeloid, Acute / genetics Mice Neoplasm Transplantation Oncogene Proteins, Fusion / genetics Transcription Factors Tumor Cells, Cultured

Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
12 2019
Historique:
received: 13 12 2018
revised: 05 08 2019
accepted: 23 09 2019
pubmed: 31 10 2019
medline: 8 8 2020
entrez: 31 10 2019
Statut: ppublish

Résumé

Fusion oncogenes are prevalent in several pediatric cancers, yet little is known about the specific associations between age and phenotype. We observed that fusion oncogenes, such as

Identifiants

DOI: 10.1158/2159-8290.CD-18-1463 PMID: 31662298
pubmed: 31662298
pii: 2159-8290.CD-18-1463
doi: 10.1158/2159-8290.CD-18-1463
doi:

Substances chimiques

ETO2-GLIS2 fusion protein, human 0
Oncogene Proteins, Fusion 0
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1736-1753

Subventions

Organisme : Medical Research Council
ID : MC_PC_12009
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0900892
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00016/7
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701761
Pays : United Kingdom
Organisme : Swiss National Science Foundation
Pays : Switzerland
Organisme : Medical Research Council
ID : MC_UU_12009/7
Pays : United Kingdom
Organisme : Blood Cancer UK
ID : 12029
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

©2019 American Association for Cancer Research.

Auteurs

Cécile K Lopez (CK)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.
Université Paris-Saclay, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.

Esteve Noguera (E)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.

Vaia Stavropoulou (V)

University Children's Hospital Beider Basel (UKBB) and Department of Biomedicine, University of Basel, Basel, Switzerland.

Elie Robert (E)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.

Zakia Aid (Z)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.

Paola Ballerini (P)

Hôpital Trousseau, AP-HP, Paris, France.

Chrystèle Bilhou-Nabera (C)

Sorbonne Université, CRSA-Unité INSERM, AP-HP, Hôpital Trousseau, Paris, France.

Hélène Lapillonne (H)

Hôpital Saint Antoine, AP-HP, Paris, France.

Fabien Boudia (F)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.
Université Paris Diderot, Paris, France.

Cécile Thirant (C)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.

Alexandre Fagnan (A)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.
Université Paris Diderot, Paris, France.

Marie-Laure Arcangeli (ML)

Unité Mixte de Recherche 967 INSERM, CEA/DRF/IBFJ/IRCM/LSHL, Université Paris-Diderot-Université Paris-Sud, Equipe labellisée Association Recherche Contre le Cancer, Fontenay-aux-roses, France.

Sarah J Kinston (SJ)

Wellcome and MRC Cambridge Stem Cell Institute and the Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

M'Boyba Diop (M)

Gustave Roussy, Villejuif, France.

Bastien Job (B)

Gustave Roussy, Villejuif, France.

Yann Lecluse (Y)

Gustave Roussy, Villejuif, France.

Erika Brunet (E)

Genome Dynamics in the Immune System Laboratory, Institut Imagine, INSERM, Université Paris Descartes, Sorbonne Paris Cité, Equipe Labellisée Ligue Contre le Cancer, Paris, France.
ORCID: 0000-0002-1726-4673

Loélia Babin (L)

Genome Dynamics in the Immune System Laboratory, Institut Imagine, INSERM, Université Paris Descartes, Sorbonne Paris Cité, Equipe Labellisée Ligue Contre le Cancer, Paris, France.

Jean Luc Villeval (JL)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.

Eric Delabesse (E)

INSERM U1037, Team 16, Center of Research of Cancerology of Toulouse, Hematology Laboratory, IUCT-Oncopole, France.

Antoine H F M Peters (AHFM)

Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.
Faculty of Sciences, University of Basel, Basel, Switzerland.

William Vainchenker (W)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.

Muriel Gaudry (M)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.

Riccardo Masetti (R)

Department of Pediatrics, "Lalla Seràgnoli," Hematology-Oncology Unit, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Franco Locatelli (F)

Department of Pediatrics, Sapienza, University of Rome, Rome, Italy.
Hematology-Oncology-IRCCS Ospedale Bambino Gesù, Rome, Italy.

Sébastien Malinge (S)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.
Université Paris-Saclay, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.
ORCID: 0000-0002-9533-7778

Claus Nerlov (C)

MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

Nathalie Droin (N)

INSERM U1170, Gustave Roussy, Villejuif, France.
ORCID: 0000-0002-6099-5324

Camille Lobry (C)

INSERM U1170, Gustave Roussy, Villejuif, France.

Isabelle Godin (I)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.
ORCID: 0000-0001-8577-8388

Olivier A Bernard (OA)

INSERM U1170, Gustave Roussy, Villejuif, France.
Gustave Roussy, Villejuif, France.
Université Paris-Saclay, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.

Berthold Göttgens (B)

Wellcome and MRC Cambridge Stem Cell Institute and the Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
ORCID: 0000-0001-6302-5705

Arnaud Petit (A)

Hôpital Trousseau, AP-HP, Paris, France.

Françoise Pflumio (F)

Unité Mixte de Recherche 967 INSERM, CEA/DRF/IBFJ/IRCM/LSHL, Université Paris-Diderot-Université Paris-Sud, Equipe labellisée Association Recherche Contre le Cancer, Fontenay-aux-roses, France.

Juerg Schwaller (J)

University Children's Hospital Beider Basel (UKBB) and Department of Biomedicine, University of Basel, Basel, Switzerland. thomas.mercher@inserm.fr j.schwaller@unibas.ch.
ORCID: 0000-0001-8616-0096

Thomas Mercher (T)

INSERM U1170, Gustave Roussy, Villejuif, France. thomas.mercher@inserm.fr j.schwaller@unibas.ch.
Gustave Roussy, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.
Université Paris Diderot, Paris, France.
ORCID: 0000-0003-1552-087X

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Eucaryotes › Animaux › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines de fusion oncogènes › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Ontogenic Changes in Hematopoietic Hierarchy...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Ontogenic Changes in Hematopoietic Hierarchy...