Thomas Mercher

Affiliations

INSERM U1170, Gustave Roussy Institute, Université Paris-Sud, Villejuif, France.

Publications (20)

SPEN integrates transcriptional and epigenetic control of X-inactivation.

Nature

Avec: François Dossin , Inês Pinheiro , Jan J Żylicz , Julia Roensch , Samuel Collombet , Agnès Le Saux , Tomasz Chelmicki , Mikaël Attia , Varun Kapoor , Ye Zhan , Florent Dingli , Damarys Loew , Thomas Mercher , Job Dekker , Edith Heard

The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53.

Blood

Avec: Maria-Riera Piqué-Borràs , Zivojin Jevtic , Frederik Otzen Bagger , Jonathan Seguin , Rathick Sivalingam , Matheus Filgueira Bezerra , Amber Louwagie , Sabine Juge , Ioannis Nellas , Robert Ivanek , Alexandar Tzankov , Ute M Moll , Oriano Cantillo , Ramona Schulz-Heddergott , Alexandre Fagnan , Thomas Mercher , Juerg Schwaller

A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.

Communications biology

Avec: Maria Eugénia Marques Da Costa , Sakina Zaidi , Jean-Yves Scoazec , Robin Droit , Wan Ching Lim , Antonin Marchais , Jerome Salmon , Sarah Cherkaoui , Raphael J Morscher , Anouchka Laurent , Sébastien Malinge , Thomas Mercher , Séverine Tabone-Eglinger , Isabelle Goddard , Francoise Pflumio , Julien Calvo , Francoise Redini , Natacha Entz-Werlé , Aroa Soriano , Alberto Villanueva , Stefano Cairo , Pascal Chastagner , Massimo Moro , Cormac Owens , Michela Casanova , Raquel Hladun-Alvaro , Pablo Berlanga , Estelle Daudigeos-Dubus , Philippe Dessen , Laurence Zitvogel , Ludovic Lacroix , Gaelle Pierron , Olivier Delattre , Gudrun Schleiermacher , Didier Surdez , Birgit Geoerger

Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia.

Molecular cancer

Avec: Verónica Alonso-Pérez , Klaudia Galant , Fabien Boudia , Elie Robert , Zakia Aid , Laurent Renou , Vilma Barroca , Saryiami Devanand , Loélia Babin , Virginie Rouiller-Fabre , Delphine Moison , Didier Busso , Guillaume Piton , Christophe Metereau , Nassera Abermil , Paola Ballerini , Pierre Hirsch , Rima Haddad , Jelena Martinovic , Arnaud Petit , Hélène Lapillonne , Erika Brunet , Thomas Mercher , Françoise Pflumio

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.

Cancer discovery

Avec: Cécile K Lopez , Esteve Noguera , Vaia Stavropoulou , Elie Robert , Zakia Aid , Paola Ballerini , Chrystèle Bilhou-Nabera , Hélène Lapillonne , Fabien Boudia , Cécile Thirant , Alexandre Fagnan , Marie-Laure Arcangeli , Sarah J Kinston , M'Boyba Diop , Bastien Job , Yann Lecluse , Erika Brunet , Loélia Babin , Jean Luc Villeval , Eric Delabesse , Antoine H F M Peters , William Vainchenker , Muriel Gaudry , Riccardo Masetti , Franco Locatelli , Sébastien Malinge , Claus Nerlov , Nathalie Droin , Camille Lobry , Isabelle Godin , Olivier A Bernard , Berthold Göttgens , Arnaud Petit , Françoise Pflumio , Juerg Schwaller , Thomas Mercher

De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells.

Molecular cancer

Avec: Loélia Babin , Alice Darchen , Elie Robert , Zakia Aid , Rosalie Borry , Claire Soudais , Marion Piganeau , Anne De Cian , Carine Giovannangeli , Olivia Bawa , Charlotte Rigaud , Jean-Yves Scoazec , Lucile Couronné , Layla Veleanu , Agata Cieslak , Vahid Asnafi , David Sibon , Laurence Lamant , Fabienne Meggetto , Thomas Mercher , Erika Brunet

Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model.

The Journal of clinical investigation

Avec: Brahim Arkoun , Elie Robert , Fabien Boudia , Stefania Mazzi , Virginie Dufour , Aurélie Siret , Yasmine Mammasse , Zakia Aid , Matthieu Vieira , Aygun Imanci , Marine Aglave , Marie Cambot , Rachel Petermann , Sylvie Souquere , Philippe Rameau , Cyril Catelain , Romain Diot , Gérard Tachdjian , Olivier Hermine , Nathalie Droin , Najet Debili , Isabelle Plo , Sébastien Malinge , Eric Soler , Hana Raslova , Thomas Mercher , William Vainchenker

High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2::GLIS2 pediatric leukemia.

Leukemia

Avec: Zakia Aid , Elie Robert , Cécile K Lopez , Maxence Bourgoin , Fabien Boudia , Melchior Le Mene , Julie Riviere , Marie Baille , Salima Benbarche , Laurent Renou , Alexandre Fagnan , Cécile Thirant , Laetitia Federici , Laure Touchard , Yann Lecluse , Anton Jetten , Birgit Geoerger , Hélène Lapillonne , Eric Solary , Muriel Gaudry , Soheil Meshinchi , Françoise Pflumio , Patrick Auberger , Camille Lobry , Arnaud Petit , Arnaud Jacquel , Thomas Mercher

A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation.

Cancer discovery

Avec: Damien Roos-Weil , Camille Decaudin , Marine Armand , Véronique Della-Valle , M'boyba K Diop , Hussein Ghamlouch , Virginie Ropars , Cécile Hérate , Diane Lara , Eric Durot , Rima Haddad , Elena Mylonas , Frederik Damm , Francoise Pflumio , Bilyana Stoilova , Marlen Metzner , Olivier Elemento , Philippe Dessen , Valérie Camara-Clayette , François-Loïc Cosset , Els Verhoeyen , Véronique Leblond , Vincent Ribrag , Pascale Cornillet-Lefebvre , Philippe Rameau , Nabih Azar , Frédéric Charlotte , Pierre Morel , Jean-Baptiste Charbonnier , Paresh Vyas , Thomas Mercher , Said Aoufouchi , Nathalie Droin , Christel Guillouf , Florence Nguyen-Khac , Olivier A Bernard

Corrigendum: Pediatric Acute Myeloid Leukemia (AML): From Genes to Models Toward Targeted Therapeutic Intervention.

Frontiers in pediatrics

Avec: Thomas Mercher , Juerg Schwaller

Nfkbie-deficiency leads to increased susceptibility to develop B-cell lymphoproliferative disorders in aged mice.

Blood cancer journal

Avec: Veronique Della-Valle , Damien Roos-Weil , Laurianne Scourzic , Enguerran Mouly , Zakia Aid , Walaa Darwiche , Yann Lecluse , Frederik Damm , Sylvie Mémet , Thomas Mercher , Said Aoufouchi , Florence Nguyen-Khac , Olivier A Bernard , Hussein Ghamlouch

Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.

Nature communications

Avec: Katharina Leonards , Marwa Almosailleakh , Samantha Tauchmann , Frederik Otzen Bagger , Cécile Thirant , Sabine Juge , Thomas Bock , Hélène Méreau , Matheus F Bezerra , Alexandar Tzankov , Robert Ivanek , Régine Losson , Antoine H F M Peters , Thomas Mercher , Juerg Schwaller

The ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300-dependent stemness program.

HemaSphere

Avec: Alexandre Fagnan , Zakia Aid , Marie Baille , Aneta Drakul , Elie Robert , Cécile K Lopez , Cécile Thirant , Yann Lecluse , Julie Rivière , Cathy Ignacimouttou , Silvia Salmoiraghi , Eduardo Anguita , Audrey Naimo , Christophe Marzac , Françoise Pflumio , Sébastien Malinge , Christian Wichmann , Yun Huang , Camille Lobry , Julie Chaumeil , Eric Soler , Jean-Pierre Bourquin , Claus Nerlov , Olivier A Bernard , Juerg Schwaller , Thomas Mercher

ETS Fight Club on Microsatellite Enhancers.

Blood cancer discovery

Avec: Thomas Mercher

Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers.

Blood

Avec: Alexandre Fagnan , Frederik Otzen Bagger , Maria-Riera Piqué-Borràs , Cathy Ignacimouttou , Alexis Caulier , Cécile K Lopez , Elie Robert , Benjamin Uzan , Véronique Gelsi-Boyer , Zakia Aid , Cécile Thirant , Ute Moll , Samantha Tauchmann , Amina Kurtovic-Kozaric , Jaroslaw Maciejewski , Christine Dierks , Orietta Spinelli , Silvia Salmoiraghi , Thomas Pabst , Kazuya Shimoda , Virginie Deleuze , Hélène Lapillonne , Connor Sweeney , Véronique De Mas , Betty Leite , Zahra Kadri , Sébastien Malinge , Stéphane de Botton , Jean-Baptiste Micol , Benjamin Kile , Catherine L Carmichael , Ilaria Iacobucci , Charles G Mullighan , Martin Carroll , Peter Valent , Olivier A Bernard , Eric Delabesse , Paresh Vyas , Daniel Birnbaum , Eduardo Anguita , Loïc Garçon , Eric Soler , Juerg Schwaller , Thomas Mercher

Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Anouchka P Laurent , Aurélie Siret , Cathy Ignacimouttou , Kunjal Panchal , M'Boyba Diop , Silvia Jenni , Yi-Chien Tsai , Damien Roos-Weil , Zakia Aid , Nais Prade , Stephanie Lagarde , Damien Plassard , Gaelle Pierron , Estelle Daudigeos , Yann Lecluse , Nathalie Droin , Beat C Bornhauser , Laurence C Cheung , John D Crispino , Muriel Gaudry , Olivier A Bernard , Elizabeth Macintyre , Carole Barin Bonnigal , Rishi S Kotecha , Birgit Geoerger , Paola Ballerini , Jean-Pierre Bourquin , Eric Delabesse , Thomas Mercher , Sebastien Malinge

Pediatric Acute Myeloid Leukemia (AML): From Genes to Models Toward Targeted Therapeutic Intervention.

Frontiers in pediatrics

Avec: Thomas Mercher , Juerg Schwaller

Molecular Landscapes and Models of Acute Erythroleukemia.

HemaSphere

Avec: Alexandre Fagnan , Maria-Riera Piqué-Borràs , Samantha Tauchmann , Thomas Mercher , Juerg Schwaller

Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia.

Science advances

Avec: Salima Benbarche , Cécile K Lopez , Eralda Salataj , Zakia Aid , Cécile Thirant , Marie-Charlotte Laiguillon , Séverine Lecourt , Yannis Belloucif , Camille Vaganay , Marion Antonini , Jiang Hu , Alexandra da Silva Babinet , Delphine Ndiaye-Lobry , Bryann Pardieu , Arnaud Petit , Alexandre Puissant , Julie Chaumeil , Thomas Mercher , Camille Lobry

Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.

Haematologica

Avec: Shannon L Carey-Smith , Maryam H Simad , Kunjal Panchal , Carlos Aya-Bonilla , Hannah Smolders , Sang Lin , Jesse D Armitage , Vivien T Nguyen , Kathryn Bentley , Jette Ford , Sajla Singh , Joyce Oommen , Anouchka P Laurent , Thomas Mercher , John D Crispino , Andrew P Montgomery , Michael Kassiou , Thierry Besson , Emmanuel Deau , Laurent Meijer , Laurence C Cheung , Rishi S Kotecha , Sébastien Malinge

Réseau de co-auteurs

Zakia Aid 10 collaborations

Juerg Schwaller 8 collaborations

Elie Robert 7 collaborations

Alexandre Fagnan 6 collaborations

Sébastien Malinge 6 collaborations

Cécile Thirant 6 collaborations

Olivier A Bernard 6 collaborations

Cécile K Lopez 5 collaborations

Yann Lecluse 5 collaborations

Fabien Boudia 4 collaborations

Arnaud Petit 4 collaborations

Hélène Lapillonne 4 collaborations

Françoise Pflumio 4 collaborations

Nathalie Droin 4 collaborations

Camille Lobry 4 collaborations

Maria-Riera Piqué-Borràs 3 collaborations

Frederik Otzen Bagger 3 collaborations

Birgit Geoerger 3 collaborations

Loélia Babin 3 collaborations

Paola Ballerini 3 collaborations

Erika Brunet 3 collaborations

Eric Delabesse 3 collaborations

Muriel Gaudry 3 collaborations

Eric Soler 3 collaborations

Damien Roos-Weil 3 collaborations

Samantha Tauchmann 3 collaborations

Cathy Ignacimouttou 3 collaborations

Sabine Juge 2 collaborations

Robert Ivanek 2 collaborations

Alexandar Tzankov 2 collaborations

Jean-Yves Scoazec 2 collaborations

Francoise Pflumio 2 collaborations

Philippe Dessen 2 collaborations

Gaelle Pierron 2 collaborations

Laurent Renou 2 collaborations

Rima Haddad 2 collaborations

M'Boyba Diop 2 collaborations

Antoine H F M Peters 2 collaborations

William Vainchenker 2 collaborations

Claus Nerlov 2 collaborations

Aurélie Siret 2 collaborations

Philippe Rameau 2 collaborations

Marie Baille 2 collaborations

Salima Benbarche 2 collaborations

Hussein Ghamlouch 2 collaborations

Frederik Damm 2 collaborations

Paresh Vyas 2 collaborations

Said Aoufouchi 2 collaborations

Florence Nguyen-Khac 2 collaborations

Silvia Salmoiraghi 2 collaborations

Eduardo Anguita 2 collaborations

Julie Chaumeil 2 collaborations

Jean-Pierre Bourquin 2 collaborations

Anouchka P Laurent 2 collaborations

Kunjal Panchal 2 collaborations

Laurence C Cheung 2 collaborations

John D Crispino 2 collaborations

Rishi S Kotecha 2 collaborations

François Dossin 1 collaboration

Inês Pinheiro 1 collaboration

Jan J Żylicz 1 collaboration

Julia Roensch 1 collaboration

Samuel Collombet 1 collaboration

Agnès Le Saux 1 collaboration

Tomasz Chelmicki 1 collaboration

Mikaël Attia 1 collaboration

Varun Kapoor 1 collaboration

Ye Zhan 1 collaboration

Florent Dingli 1 collaboration

Damarys Loew 1 collaboration

Job Dekker 1 collaboration

Edith Heard 1 collaboration

Zivojin Jevtic 1 collaboration

Jonathan Seguin 1 collaboration

Rathick Sivalingam 1 collaboration

Matheus Filgueira Bezerra 1 collaboration

Amber Louwagie 1 collaboration

Ioannis Nellas 1 collaboration

Ute M Moll 1 collaboration

Oriano Cantillo 1 collaboration

Ramona Schulz-Heddergott 1 collaboration

Maria Eugénia Marques Da Costa 1 collaboration

Sakina Zaidi 1 collaboration

Robin Droit 1 collaboration

Wan Ching Lim 1 collaboration

Antonin Marchais 1 collaboration

Jerome Salmon 1 collaboration

Sarah Cherkaoui 1 collaboration

Raphael J Morscher 1 collaboration

Anouchka Laurent 1 collaboration

Séverine Tabone-Eglinger 1 collaboration

Isabelle Goddard 1 collaboration

Julien Calvo 1 collaboration

Francoise Redini 1 collaboration

Natacha Entz-Werlé 1 collaboration

Aroa Soriano 1 collaboration

Alberto Villanueva 1 collaboration

Stefano Cairo 1 collaboration

Pascal Chastagner 1 collaboration

Massimo Moro 1 collaboration

Cormac Owens 1 collaboration

Michela Casanova 1 collaboration

Raquel Hladun-Alvaro 1 collaboration

Pablo Berlanga 1 collaboration

Estelle Daudigeos-Dubus 1 collaboration

Laurence Zitvogel 1 collaboration

Ludovic Lacroix 1 collaboration

Olivier Delattre 1 collaboration

Gudrun Schleiermacher 1 collaboration

Didier Surdez 1 collaboration

Verónica Alonso-Pérez 1 collaboration

Klaudia Galant 1 collaboration

Vilma Barroca 1 collaboration

Saryiami Devanand 1 collaboration

Virginie Rouiller-Fabre 1 collaboration

Delphine Moison 1 collaboration

Didier Busso 1 collaboration

Guillaume Piton 1 collaboration

Christophe Metereau 1 collaboration

Nassera Abermil 1 collaboration

Pierre Hirsch 1 collaboration

Jelena Martinovic 1 collaboration

Esteve Noguera 1 collaboration

Vaia Stavropoulou 1 collaboration

Chrystèle Bilhou-Nabera 1 collaboration

Marie-Laure Arcangeli 1 collaboration

Sarah J Kinston 1 collaboration

Bastien Job 1 collaboration

Jean Luc Villeval 1 collaboration

Riccardo Masetti 1 collaboration

Franco Locatelli 1 collaboration

Isabelle Godin 1 collaboration

Berthold Göttgens 1 collaboration

Alice Darchen 1 collaboration

Rosalie Borry 1 collaboration

Claire Soudais 1 collaboration

Marion Piganeau 1 collaboration

Anne De Cian 1 collaboration

Carine Giovannangeli 1 collaboration

Olivia Bawa 1 collaboration

Charlotte Rigaud 1 collaboration

Lucile Couronné 1 collaboration

Layla Veleanu 1 collaboration

Agata Cieslak 1 collaboration

Vahid Asnafi 1 collaboration

David Sibon 1 collaboration

Laurence Lamant 1 collaboration

Fabienne Meggetto 1 collaboration

Brahim Arkoun 1 collaboration

Stefania Mazzi 1 collaboration

Virginie Dufour 1 collaboration

Yasmine Mammasse 1 collaboration

Matthieu Vieira 1 collaboration

Aygun Imanci 1 collaboration

Marine Aglave 1 collaboration

Marie Cambot 1 collaboration

Rachel Petermann 1 collaboration

Sylvie Souquere 1 collaboration

Cyril Catelain 1 collaboration

Romain Diot 1 collaboration

Gérard Tachdjian 1 collaboration

Olivier Hermine 1 collaboration

Najet Debili 1 collaboration

Isabelle Plo 1 collaboration

Hana Raslova 1 collaboration

Maxence Bourgoin 1 collaboration

Melchior Le Mene 1 collaboration

Julie Riviere 1 collaboration

Laetitia Federici 1 collaboration

Laure Touchard 1 collaboration

Anton Jetten 1 collaboration

Eric Solary 1 collaboration

Soheil Meshinchi 1 collaboration

Patrick Auberger 1 collaboration

Arnaud Jacquel 1 collaboration

Camille Decaudin 1 collaboration

Marine Armand 1 collaboration

Véronique Della-Valle 1 collaboration

M'boyba K Diop 1 collaboration

Virginie Ropars 1 collaboration

Cécile Hérate 1 collaboration

Diane Lara 1 collaboration

Eric Durot 1 collaboration

Elena Mylonas 1 collaboration

Bilyana Stoilova 1 collaboration

Marlen Metzner 1 collaboration

Olivier Elemento 1 collaboration

Valérie Camara-Clayette 1 collaboration

François-Loïc Cosset 1 collaboration

Els Verhoeyen 1 collaboration

Véronique Leblond 1 collaboration

Vincent Ribrag 1 collaboration

Pascale Cornillet-Lefebvre 1 collaboration

Nabih Azar 1 collaboration

Frédéric Charlotte 1 collaboration

Pierre Morel 1 collaboration

Jean-Baptiste Charbonnier 1 collaboration

Christel Guillouf 1 collaboration

Veronique Della-Valle 1 collaboration

Laurianne Scourzic 1 collaboration

Enguerran Mouly 1 collaboration

Walaa Darwiche 1 collaboration

Sylvie Mémet 1 collaboration

Katharina Leonards 1 collaboration

Marwa Almosailleakh 1 collaboration

Thomas Bock 1 collaboration

Hélène Méreau 1 collaboration

Matheus F Bezerra 1 collaboration

Régine Losson 1 collaboration

Aneta Drakul 1 collaboration

Julie Rivière 1 collaboration

Audrey Naimo 1 collaboration

Christophe Marzac 1 collaboration

Christian Wichmann 1 collaboration

Yun Huang 1 collaboration

Alexis Caulier 1 collaboration

Benjamin Uzan 1 collaboration

Véronique Gelsi-Boyer 1 collaboration

Ute Moll 1 collaboration

Amina Kurtovic-Kozaric 1 collaboration

Jaroslaw Maciejewski 1 collaboration

Christine Dierks 1 collaboration

Orietta Spinelli 1 collaboration

Thomas Pabst 1 collaboration

Kazuya Shimoda 1 collaboration

Virginie Deleuze 1 collaboration

Connor Sweeney 1 collaboration

Véronique De Mas 1 collaboration

Betty Leite 1 collaboration

Zahra Kadri 1 collaboration

Stéphane de Botton 1 collaboration

Jean-Baptiste Micol 1 collaboration

Benjamin Kile 1 collaboration

Catherine L Carmichael 1 collaboration

Ilaria Iacobucci 1 collaboration

Charles G Mullighan 1 collaboration

Martin Carroll 1 collaboration

Peter Valent 1 collaboration

Daniel Birnbaum 1 collaboration

Loïc Garçon 1 collaboration

Silvia Jenni 1 collaboration

Yi-Chien Tsai 1 collaboration

Nais Prade 1 collaboration

Stephanie Lagarde 1 collaboration

Damien Plassard 1 collaboration

Estelle Daudigeos 1 collaboration

Beat C Bornhauser 1 collaboration

Elizabeth Macintyre 1 collaboration

Carole Barin Bonnigal 1 collaboration

Sebastien Malinge 1 collaboration

Eralda Salataj 1 collaboration

Marie-Charlotte Laiguillon 1 collaboration

Séverine Lecourt 1 collaboration

Yannis Belloucif 1 collaboration

Camille Vaganay 1 collaboration

Marion Antonini 1 collaboration

Jiang Hu 1 collaboration

Alexandra da Silva Babinet 1 collaboration

Delphine Ndiaye-Lobry 1 collaboration

Bryann Pardieu 1 collaboration

Alexandre Puissant 1 collaboration

Shannon L Carey-Smith 1 collaboration

Maryam H Simad 1 collaboration

Carlos Aya-Bonilla 1 collaboration

Hannah Smolders 1 collaboration

Sang Lin 1 collaboration

Jesse D Armitage 1 collaboration

Vivien T Nguyen 1 collaboration

Kathryn Bentley 1 collaboration

Jette Ford 1 collaboration

Sajla Singh 1 collaboration

Joyce Oommen 1 collaboration

Andrew P Montgomery 1 collaboration

Michael Kassiou 1 collaboration

Thierry Besson 1 collaboration

Emmanuel Deau 1 collaboration

Laurent Meijer 1 collaboration