ETS Fight Club on Microsatellite Enhancers.
Journal
Blood cancer discovery
ISSN: 2643-3249
Titre abrégé: Blood Cancer Discov
Pays: United States
ID NLM: 101764786
Informations de publication
Date de publication:
06 01 2023
06 01 2023
Historique:
pubmed:
21
12
2022
medline:
10
1
2023
entrez:
20
12
2022
Statut:
ppublish
Résumé
In this issue of Blood Cancer Discovery, Kodgule, Goldman, Monovichet al. cleverly analyzed the transcription regulatory elements to investigate why the second copy of ETV6 is often lost in ETV6::RUNX1-translocated in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It turns out that ETV6 suppresses the enhancer activity of GGAA microsatellite repeats, preventing ERG from subverting them to activate aberrant oncogene transcription. See related article by Kodgule, Goldman, Monovich et al., p. 34 (5).
Identifiants
pubmed: 36538046
pii: 712646
doi: 10.1158/2643-3230.BCD-22-0177
pmc: PMC9816819
doi:
Substances chimiques
Oncogene Proteins, Fusion
0
ERG protein, human
0
Transcriptional Regulator ERG
0
Types de publication
Editorial
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
2-4Commentaires et corrections
Type : CommentOn
Informations de copyright
©2022 American Association for Cancer Research.
Références
Cell. 1994 Jul 15;78(1):137-47
pubmed: 8033205
Nat Rev Cancer. 2017 Jun;17(6):337-351
pubmed: 28450705
Nat Genet. 2015 Sep;47(9):1073-8
pubmed: 26214589
Oncogene. 2004 May 24;23(24):4275-83
pubmed: 15156184
Semin Cancer Biol. 2005 Jun;15(3):162-74
pubmed: 15826831
J Biol Chem. 2003 Oct 17;278(42):41316-25
pubmed: 12893822
Blood Cancer Discov. 2022 Sep 6;3(5):444-467
pubmed: 35820129
N Engl J Med. 2021 Jan 14;384(2):154-164
pubmed: 33497548
Blood Cancer Discov. 2023 Jan 6;4(1):34-53
pubmed: 36350827
Nat Genet. 2015 May;47(5):535-538
pubmed: 25807284