Sebastien Malinge

Affiliations

Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia.
School of Medicine, University of Western Australia, Perth, WA, Australia.

Publications (17)

The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution.

Scientific reports

Avec: Denise Anderson , Patrycja Skut , Anastasia M Hughes , Emanuela Ferrari , Jennifer Tickner , Jiake Xu , Benjamin H Mullin , Dave Tang , Sébastien Malinge , Ursula R Kees , Rishi S Kotecha , Timo Lassmann , Laurence C Cheung

The ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300-dependent stemness program.

HemaSphere

Avec: Alexandre Fagnan , Zakia Aid , Marie Baille , Aneta Drakul , Elie Robert , Cécile K Lopez , Cécile Thirant , Yann Lecluse , Julie Rivière , Cathy Ignacimouttou , Silvia Salmoiraghi , Eduardo Anguita , Audrey Naimo , Christophe Marzac , Françoise Pflumio , Sébastien Malinge , Christian Wichmann , Yun Huang , Camille Lobry , Julie Chaumeil , Eric Soler , Jean-Pierre Bourquin , Claus Nerlov , Olivier A Bernard , Juerg Schwaller , Thomas Mercher

Preclinical Evaluation of Carfilzomib for Infant

Frontiers in oncology

Avec: Laurence C Cheung , Rebecca de Kraa , Joyce Oommen , Grace-Alyssa Chua , Sajla Singh , Anastasia M Hughes , Emanuela Ferrari , Jette Ford , Sung K Chiu , Ronald W Stam , Ursula R Kees , Sébastien Malinge , Rishi S Kotecha

DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.

The Journal of clinical investigation

Avec: Rahul S Bhansali , Malini Rammohan , Paul Lee , Anouchka P Laurent , Qiang Wen , Praveen Suraneni , Bon Ham Yip , Yi-Chien Tsai , Silvia Jenni , Beat Bornhauser , Aurélie Siret , Corinne Fruit , Alexandra Pacheco-Benichou , Ethan Harris , Thierry Besson , Benjamin J Thompson , Young Ah Goo , Nobuko Hijiya , Maria Vilenchik , Shai Izraeli , Jean-Pierre Bourquin , Sébastien Malinge , John D Crispino

Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia.

Frontiers in cell and developmental biology

Avec: Anastasia M Hughes , Vincent Kuek , Joyce Oommen , Grace-Alyssa Chua , Maria van Loenhout , Sebastien Malinge , Rishi S Kotecha , Laurence C Cheung

Down syndrome and leukemia: from basic mechanisms to clinical advances.

Haematologica

Avec: André Baruchel , Jean-Pierre Bourquin , John Crispino , Sergi Cuartero , Henrik Hasle , Johann Hitzler , Jan-Henning Klusmann , Shai Izraeli , Andrew A Lane , Sébastien Malinge , Karen R Rabin , Irene Roberts , Sandra Ryeom , Sarah K Tasian , Elvin Wagenblast

A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.

Communications biology

Avec: Maria Eugénia Marques Da Costa , Sakina Zaidi , Jean-Yves Scoazec , Robin Droit , Wan Ching Lim , Antonin Marchais , Jerome Salmon , Sarah Cherkaoui , Raphael J Morscher , Anouchka Laurent , Sébastien Malinge , Thomas Mercher , Séverine Tabone-Eglinger , Isabelle Goddard , Francoise Pflumio , Julien Calvo , Francoise Redini , Natacha Entz-Werlé , Aroa Soriano , Alberto Villanueva , Stefano Cairo , Pascal Chastagner , Massimo Moro , Cormac Owens , Michela Casanova , Raquel Hladun-Alvaro , Pablo Berlanga , Estelle Daudigeos-Dubus , Philippe Dessen , Laurence Zitvogel , Ludovic Lacroix , Gaelle Pierron , Olivier Delattre , Gudrun Schleiermacher , Didier Surdez , Birgit Geoerger

Ontogenic Changes in Hematopoietic Hierarchy Determine Pediatric Specificity and Disease Phenotype in Fusion Oncogene-Driven Myeloid Leukemia.

Cancer discovery

Avec: Cécile K Lopez , Esteve Noguera , Vaia Stavropoulou , Elie Robert , Zakia Aid , Paola Ballerini , Chrystèle Bilhou-Nabera , Hélène Lapillonne , Fabien Boudia , Cécile Thirant , Alexandre Fagnan , Marie-Laure Arcangeli , Sarah J Kinston , M'Boyba Diop , Bastien Job , Yann Lecluse , Erika Brunet , Loélia Babin , Jean Luc Villeval , Eric Delabesse , Antoine H F M Peters , William Vainchenker , Muriel Gaudry , Riccardo Masetti , Franco Locatelli , Sébastien Malinge , Claus Nerlov , Nathalie Droin , Camille Lobry , Isabelle Godin , Olivier A Bernard , Berthold Göttgens , Arnaud Petit , Françoise Pflumio , Juerg Schwaller , Thomas Mercher

Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome.

Leukemia

Avec: Anouchka P Laurent , Rishi S Kotecha , Sébastien Malinge

Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.

Molecular syndromology

Avec: Mara Dierssen , Yann Herault , Pablo Helguera , Maria Martínez de Lagran , Anna Vazquez , Bradley Christian , Maria Carmona-Iragui , Frances Wiseman , William Mobley , Elizabeth M C Fisher , Veronique Brault , Anna Esbensen , Lisa M Jacola , Marie Claude Potier , Eric D Hamlett , Leonard Abbeduto , Laura Del Hoyo Soriano , Jorge Busciglio , Maria Florencia Iulita , John Crispino , Sébastien Malinge , Eugenio Barone , Marzia Perluigi , Floriana Costanzo , Jean Maurice Delabar , Renata Bartesaghi , Alain D Dekker , Peter De Deyn , Juan Fortea Ormaechea , Patricia A Shaw , Tarik F Haydar , Stephanie L Sherman , André Strydom , Anita Bhattacharyya

Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model.

The Journal of clinical investigation

Avec: Brahim Arkoun , Elie Robert , Fabien Boudia , Stefania Mazzi , Virginie Dufour , Aurélie Siret , Yasmine Mammasse , Zakia Aid , Matthieu Vieira , Aygun Imanci , Marine Aglave , Marie Cambot , Rachel Petermann , Sylvie Souquere , Philippe Rameau , Cyril Catelain , Romain Diot , Gérard Tachdjian , Olivier Hermine , Nathalie Droin , Najet Debili , Isabelle Plo , Sébastien Malinge , Eric Soler , Hana Raslova , Thomas Mercher , William Vainchenker

Disruption of cotranscriptional splicing suggests that RBM39 is a therapeutic target in acute lymphoblastic leukemia.

Blood

Avec: Qi Jin , Ethan Harris , Jacquelyn A Myers , Rashid Mehmood , Anitria Cotton , Hazheen K Shirnekhi , David W Baggett , Jeremy Qiang Wen , Andrew B Schild , Rahul S Bhansali , Jonathon Klein , Shilpa Narina , Tim Pieters , Akihide Yoshimi , Shondra M Pruett-Miller , Richard Kriwacki , Omar Abdel-Wahab , Sebastien Malinge , Panagiotis Ntziachristos , Esther A Obeng , John D Crispino

Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers.

Blood

Avec: Alexandre Fagnan , Frederik Otzen Bagger , Maria-Riera Piqué-Borràs , Cathy Ignacimouttou , Alexis Caulier , Cécile K Lopez , Elie Robert , Benjamin Uzan , Véronique Gelsi-Boyer , Zakia Aid , Cécile Thirant , Ute Moll , Samantha Tauchmann , Amina Kurtovic-Kozaric , Jaroslaw Maciejewski , Christine Dierks , Orietta Spinelli , Silvia Salmoiraghi , Thomas Pabst , Kazuya Shimoda , Virginie Deleuze , Hélène Lapillonne , Connor Sweeney , Véronique De Mas , Betty Leite , Zahra Kadri , Sébastien Malinge , Stéphane de Botton , Jean-Baptiste Micol , Benjamin Kile , Catherine L Carmichael , Ilaria Iacobucci , Charles G Mullighan , Martin Carroll , Peter Valent , Olivier A Bernard , Eric Delabesse , Paresh Vyas , Daniel Birnbaum , Eduardo Anguita , Loïc Garçon , Eric Soler , Juerg Schwaller , Thomas Mercher

Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Anouchka P Laurent , Aurélie Siret , Cathy Ignacimouttou , Kunjal Panchal , M'Boyba Diop , Silvia Jenni , Yi-Chien Tsai , Damien Roos-Weil , Zakia Aid , Nais Prade , Stephanie Lagarde , Damien Plassard , Gaelle Pierron , Estelle Daudigeos , Yann Lecluse , Nathalie Droin , Beat C Bornhauser , Laurence C Cheung , John D Crispino , Muriel Gaudry , Olivier A Bernard , Elizabeth Macintyre , Carole Barin Bonnigal , Rishi S Kotecha , Birgit Geoerger , Paola Ballerini , Jean-Pierre Bourquin , Eric Delabesse , Thomas Mercher , Sebastien Malinge

Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy.

Leukemia

Avec: Laurence C Cheung , Carlos Aya-Bonilla , Mark N Cruickshank , Sung K Chiu , Vincent Kuek , Denise Anderson , Grace-Alyssa Chua , Sajla Singh , Joyce Oommen , Emanuela Ferrari , Anastasia M Hughes , Jette Ford , Elena Kunold , Maria C Hesselman , Frederik Post , Kelly E Faulk , Erin H Breese , Erin M Guest , Patrick A Brown , Mignon L Loh , Richard B Lock , Ursula R Kees , Rozbeh Jafari , Sébastien Malinge , Rishi S Kotecha

Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.

Haematologica

Avec: Shannon L Carey-Smith , Maryam H Simad , Kunjal Panchal , Carlos Aya-Bonilla , Hannah Smolders , Sang Lin , Jesse D Armitage , Vivien T Nguyen , Kathryn Bentley , Jette Ford , Sajla Singh , Joyce Oommen , Anouchka P Laurent , Thomas Mercher , John D Crispino , Andrew P Montgomery , Michael Kassiou , Thierry Besson , Emmanuel Deau , Laurent Meijer , Laurence C Cheung , Rishi S Kotecha , Sébastien Malinge

Insights into the Clinical, Biological and Therapeutic Impact of Copy Number Alteration in Cancer.

International journal of molecular sciences

Avec: Shannon L Carey-Smith , Rishi S Kotecha , Laurence C Cheung , Sébastien Malinge

Réseau de co-auteurs

Sébastien Malinge 14 collaborations

Rishi S Kotecha 8 collaborations

Laurence C Cheung 7 collaborations

Thomas Mercher 7 collaborations

Zakia Aid 5 collaborations

Anastasia M Hughes 4 collaborations

Elie Robert 4 collaborations

Jean-Pierre Bourquin 4 collaborations

Olivier A Bernard 4 collaborations

Joyce Oommen 4 collaborations

Anouchka P Laurent 4 collaborations

John D Crispino 4 collaborations

Emanuela Ferrari 3 collaborations

Ursula R Kees 3 collaborations

Alexandre Fagnan 3 collaborations

Cécile K Lopez 3 collaborations

Cécile Thirant 3 collaborations

Yann Lecluse 3 collaborations

Cathy Ignacimouttou 3 collaborations

Eric Soler 3 collaborations

Juerg Schwaller 3 collaborations

Grace-Alyssa Chua 3 collaborations

Sajla Singh 3 collaborations

Jette Ford 3 collaborations

Aurélie Siret 3 collaborations

Eric Delabesse 3 collaborations

Nathalie Droin 3 collaborations

Denise Anderson 2 collaborations

Silvia Salmoiraghi 2 collaborations

Eduardo Anguita 2 collaborations

Françoise Pflumio 2 collaborations

Camille Lobry 2 collaborations

Claus Nerlov 2 collaborations

Sung K Chiu 2 collaborations

Rahul S Bhansali 2 collaborations

Yi-Chien Tsai 2 collaborations

Silvia Jenni 2 collaborations

Ethan Harris 2 collaborations

Thierry Besson 2 collaborations

Shai Izraeli 2 collaborations

Vincent Kuek 2 collaborations

John Crispino 2 collaborations

Gaelle Pierron 2 collaborations

Birgit Geoerger 2 collaborations

Paola Ballerini 2 collaborations

Hélène Lapillonne 2 collaborations

Fabien Boudia 2 collaborations

M'Boyba Diop 2 collaborations

William Vainchenker 2 collaborations

Muriel Gaudry 2 collaborations

Kunjal Panchal 2 collaborations

Carlos Aya-Bonilla 2 collaborations

Shannon L Carey-Smith 2 collaborations

Patrycja Skut 1 collaboration

Jennifer Tickner 1 collaboration

Jiake Xu 1 collaboration

Benjamin H Mullin 1 collaboration

Dave Tang 1 collaboration

Timo Lassmann 1 collaboration

Marie Baille 1 collaboration

Aneta Drakul 1 collaboration

Julie Rivière 1 collaboration

Audrey Naimo 1 collaboration

Christophe Marzac 1 collaboration

Christian Wichmann 1 collaboration

Yun Huang 1 collaboration

Julie Chaumeil 1 collaboration

Rebecca de Kraa 1 collaboration

Ronald W Stam 1 collaboration

Malini Rammohan 1 collaboration

Paul Lee 1 collaboration

Qiang Wen 1 collaboration

Praveen Suraneni 1 collaboration

Bon Ham Yip 1 collaboration

Beat Bornhauser 1 collaboration

Corinne Fruit 1 collaboration

Alexandra Pacheco-Benichou 1 collaboration

Benjamin J Thompson 1 collaboration

Young Ah Goo 1 collaboration

Nobuko Hijiya 1 collaboration

Maria Vilenchik 1 collaboration

Maria van Loenhout 1 collaboration

André Baruchel 1 collaboration

Sergi Cuartero 1 collaboration

Henrik Hasle 1 collaboration

Johann Hitzler 1 collaboration

Jan-Henning Klusmann 1 collaboration

Andrew A Lane 1 collaboration

Karen R Rabin 1 collaboration

Irene Roberts 1 collaboration

Sandra Ryeom 1 collaboration

Sarah K Tasian 1 collaboration

Elvin Wagenblast 1 collaboration

Maria Eugénia Marques Da Costa 1 collaboration

Sakina Zaidi 1 collaboration

Jean-Yves Scoazec 1 collaboration

Robin Droit 1 collaboration

Wan Ching Lim 1 collaboration

Antonin Marchais 1 collaboration

Jerome Salmon 1 collaboration

Sarah Cherkaoui 1 collaboration

Raphael J Morscher 1 collaboration

Anouchka Laurent 1 collaboration

Séverine Tabone-Eglinger 1 collaboration

Isabelle Goddard 1 collaboration

Francoise Pflumio 1 collaboration

Julien Calvo 1 collaboration

Francoise Redini 1 collaboration

Natacha Entz-Werlé 1 collaboration

Aroa Soriano 1 collaboration

Alberto Villanueva 1 collaboration

Stefano Cairo 1 collaboration

Pascal Chastagner 1 collaboration

Massimo Moro 1 collaboration

Cormac Owens 1 collaboration

Michela Casanova 1 collaboration

Raquel Hladun-Alvaro 1 collaboration

Pablo Berlanga 1 collaboration

Estelle Daudigeos-Dubus 1 collaboration

Philippe Dessen 1 collaboration

Laurence Zitvogel 1 collaboration

Ludovic Lacroix 1 collaboration

Olivier Delattre 1 collaboration

Gudrun Schleiermacher 1 collaboration

Didier Surdez 1 collaboration

Esteve Noguera 1 collaboration

Vaia Stavropoulou 1 collaboration

Chrystèle Bilhou-Nabera 1 collaboration

Marie-Laure Arcangeli 1 collaboration

Sarah J Kinston 1 collaboration

Bastien Job 1 collaboration

Erika Brunet 1 collaboration

Loélia Babin 1 collaboration

Jean Luc Villeval 1 collaboration

Antoine H F M Peters 1 collaboration

Riccardo Masetti 1 collaboration

Franco Locatelli 1 collaboration

Isabelle Godin 1 collaboration

Berthold Göttgens 1 collaboration

Arnaud Petit 1 collaboration

Mara Dierssen 1 collaboration

Yann Herault 1 collaboration

Pablo Helguera 1 collaboration

Maria Martínez de Lagran 1 collaboration

Anna Vazquez 1 collaboration

Bradley Christian 1 collaboration

Maria Carmona-Iragui 1 collaboration

Frances Wiseman 1 collaboration

William Mobley 1 collaboration

Elizabeth M C Fisher 1 collaboration

Veronique Brault 1 collaboration

Anna Esbensen 1 collaboration

Lisa M Jacola 1 collaboration

Marie Claude Potier 1 collaboration

Eric D Hamlett 1 collaboration

Leonard Abbeduto 1 collaboration

Laura Del Hoyo Soriano 1 collaboration

Jorge Busciglio 1 collaboration

Maria Florencia Iulita 1 collaboration

Eugenio Barone 1 collaboration

Marzia Perluigi 1 collaboration

Floriana Costanzo 1 collaboration

Jean Maurice Delabar 1 collaboration

Renata Bartesaghi 1 collaboration

Alain D Dekker 1 collaboration

Peter De Deyn 1 collaboration

Juan Fortea Ormaechea 1 collaboration

Patricia A Shaw 1 collaboration

Tarik F Haydar 1 collaboration

Stephanie L Sherman 1 collaboration

André Strydom 1 collaboration

Anita Bhattacharyya 1 collaboration

Brahim Arkoun 1 collaboration

Stefania Mazzi 1 collaboration

Virginie Dufour 1 collaboration

Yasmine Mammasse 1 collaboration

Matthieu Vieira 1 collaboration

Aygun Imanci 1 collaboration

Marine Aglave 1 collaboration

Marie Cambot 1 collaboration

Rachel Petermann 1 collaboration

Sylvie Souquere 1 collaboration

Philippe Rameau 1 collaboration

Cyril Catelain 1 collaboration

Romain Diot 1 collaboration

Gérard Tachdjian 1 collaboration

Olivier Hermine 1 collaboration

Najet Debili 1 collaboration

Isabelle Plo 1 collaboration

Hana Raslova 1 collaboration

Qi Jin 1 collaboration

Jacquelyn A Myers 1 collaboration

Rashid Mehmood 1 collaboration

Anitria Cotton 1 collaboration

Hazheen K Shirnekhi 1 collaboration

David W Baggett 1 collaboration

Jeremy Qiang Wen 1 collaboration

Andrew B Schild 1 collaboration

Jonathon Klein 1 collaboration

Shilpa Narina 1 collaboration

Tim Pieters 1 collaboration

Akihide Yoshimi 1 collaboration

Shondra M Pruett-Miller 1 collaboration

Richard Kriwacki 1 collaboration

Omar Abdel-Wahab 1 collaboration

Panagiotis Ntziachristos 1 collaboration

Esther A Obeng 1 collaboration

Frederik Otzen Bagger 1 collaboration

Maria-Riera Piqué-Borràs 1 collaboration

Alexis Caulier 1 collaboration

Benjamin Uzan 1 collaboration

Véronique Gelsi-Boyer 1 collaboration

Ute Moll 1 collaboration

Samantha Tauchmann 1 collaboration

Amina Kurtovic-Kozaric 1 collaboration

Jaroslaw Maciejewski 1 collaboration

Christine Dierks 1 collaboration

Orietta Spinelli 1 collaboration

Thomas Pabst 1 collaboration

Kazuya Shimoda 1 collaboration

Virginie Deleuze 1 collaboration

Connor Sweeney 1 collaboration

Véronique De Mas 1 collaboration

Betty Leite 1 collaboration

Zahra Kadri 1 collaboration

Stéphane de Botton 1 collaboration

Jean-Baptiste Micol 1 collaboration

Benjamin Kile 1 collaboration

Catherine L Carmichael 1 collaboration

Ilaria Iacobucci 1 collaboration

Charles G Mullighan 1 collaboration

Martin Carroll 1 collaboration

Peter Valent 1 collaboration

Paresh Vyas 1 collaboration

Daniel Birnbaum 1 collaboration

Loïc Garçon 1 collaboration

Damien Roos-Weil 1 collaboration

Nais Prade 1 collaboration

Stephanie Lagarde 1 collaboration

Damien Plassard 1 collaboration

Estelle Daudigeos 1 collaboration

Beat C Bornhauser 1 collaboration

Elizabeth Macintyre 1 collaboration

Carole Barin Bonnigal 1 collaboration

Mark N Cruickshank 1 collaboration

Elena Kunold 1 collaboration

Maria C Hesselman 1 collaboration

Frederik Post 1 collaboration

Kelly E Faulk 1 collaboration

Erin H Breese 1 collaboration

Erin M Guest 1 collaboration

Patrick A Brown 1 collaboration

Mignon L Loh 1 collaboration

Richard B Lock 1 collaboration

Rozbeh Jafari 1 collaboration

Maryam H Simad 1 collaboration

Hannah Smolders 1 collaboration

Sang Lin 1 collaboration

Jesse D Armitage 1 collaboration

Vivien T Nguyen 1 collaboration

Kathryn Bentley 1 collaboration

Andrew P Montgomery 1 collaboration

Michael Kassiou 1 collaboration

Emmanuel Deau 1 collaboration

Laurent Meijer 1 collaboration