Mcl-1 Interacts with Akt to Promote Lung Cancer Progression.
Animals
Antineoplastic Agents
/ pharmacology
CRISPR-Cas Systems
/ genetics
Carcinoma, Non-Small-Cell Lung
/ drug therapy
Cell Line, Tumor
Disease Progression
Follow-Up Studies
Gene Knockout Techniques
Humans
Kaplan-Meier Estimate
Lung
/ pathology
Lung Neoplasms
/ drug therapy
Male
Mice
Molecular Docking Simulation
Myeloid Cell Leukemia Sequence 1 Protein
/ genetics
Prognosis
Protein Binding
/ drug effects
Protein Domains
/ drug effects
Proto-Oncogene Proteins c-akt
/ antagonists & inhibitors
Signal Transduction
/ drug effects
Tissue Array Analysis
Xenograft Model Antitumor Assays
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 12 2019
15 12 2019
Historique:
received:
20
03
2019
revised:
23
09
2019
accepted:
23
10
2019
pubmed:
31
10
2019
medline:
28
5
2020
entrez:
31
10
2019
Statut:
ppublish
Résumé
Mcl-1 is a unique antiapoptotic Bcl2 family protein that functions as a gatekeeper in manipulating apoptosis and survival in cancer cells. Akt is an oncogenic kinase that regulates multiple cellular functions and its activity is significantly elevated in human cancers. Here we discovered a cross-talk between Mcl-1 and Akt in promoting lung cancer cell growth. Depletion of endogenous Mcl-1 from human lung cancer cells using CRISPR/Cas9 or
Identifiants
pubmed: 31662324
pii: 0008-5472.CAN-19-0950
doi: 10.1158/0008-5472.CAN-19-0950
pmc: PMC6911632
mid: NIHMS1541634
doi:
Substances chimiques
Antineoplastic Agents
0
MCL1 protein, human
0
Myeloid Cell Leukemia Sequence 1 Protein
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6126-6138Subventions
Organisme : NCI NIH HHS
ID : R01 CA200905
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA217691
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA138292
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193828
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA136534
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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