Aβ modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism.

Actin Cytoskeleton / metabolism Adaptor Proteins, Signal Transducing / genetics Alzheimer Disease / genetics Amyloid beta-Peptides / genetics Cell Line Endosomes / genetics GTPase-Activating Proteins / genetics Humans Lysosomes / genetics Phosphatidylinositol Phosphates / genetics Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases / genetics Signal Transduction rhoA GTP-Binding Protein / genetics

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
29 10 2019
Historique:
received: 04 06 2019
accepted: 02 10 2019
entrez: 31 10 2019
pubmed: 31 10 2019
medline: 29 10 2020
Statut: epublish

Résumé

Emerging evidences suggest that phospholipid metabolism is altered in Alzheimer's disease (AD), but molecular mechanisms on how this affects neurodegeneration in AD is poorly understood. SHIP2 is a phosphoinositide-metabolizing enzyme, which dephosphorylates PI(3,4,5)P

Identifiants

DOI: 10.1038/s41598-019-51914-2 PMID: 31664099 PMC: PMC6820556
pubmed: 31664099
doi: 10.1038/s41598-019-51914-2
pii: 10.1038/s41598-019-51914-2
pmc: PMC6820556
doi:

Substances chimiques

ARAP3 protein, human 0
Adaptor Proteins, Signal Transducing 0
Amyloid beta-Peptides 0
GTPase-Activating Proteins 0
Phosphatidylinositol Phosphates 0
phosphatidylinositol 3,4-diphosphate 0
RHOA protein, human 124671-05-2
INPPL1 protein, human EC 3.1.3.86
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases EC 3.1.3.86
rhoA GTP-Binding Protein EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15557

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Auteurs

Hae Nim Lee (HN)

Convergence Research Center for Diagnosis Treatment Care of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.

Kyoung Mi Sim (KM)

Convergence Research Center for Diagnosis Treatment Care of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Department of Integrated Biomedical and Life Science, Korea University, Seoul, 02708, Republic of Korea.

Hyunbin Kim (H)

Convergence Research Center for Diagnosis Treatment Care of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Department of Converging Science and Technology, Kyung Hee University, Seoul, 02453, Republic of Korea.

Jeongmin Ju (J)

Convergence Research Center for Diagnosis Treatment Care of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea.

Ae Nim Pae (AN)

Convergence Research Center for Diagnosis Treatment Care of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Department of Converging Science and Technology, Kyung Hee University, Seoul, 02453, Republic of Korea.
Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea.

Jae-Bong Park (JB)

Department of Biochemistry, Hallym University College of Medicine, Chuncheon, 24252, Republic of Korea.

Hoon Ryu (H)

Center for Neuroscience, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.

Jihye Seong (J)

Convergence Research Center for Diagnosis Treatment Care of Dementia, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea. jseong@kist.re.kr.
Department of Converging Science and Technology, Kyung Hee University, Seoul, 02453, Republic of Korea. jseong@kist.re.kr.
Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea. jseong@kist.re.kr.

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Cytosquelette d'actine › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Protéines d'activation de la GTPase › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › Phosphates phosphatidylinositol › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Phosphoinositide phosphatases › Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatases › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Aβ modulates actin cytoskeleton via...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Protéine G RhoA › Aβ modulates actin cytoskeleton via...