The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
21
06
2019
accepted:
17
10
2019
revised:
24
09
2019
pubmed:
31
10
2019
medline:
28
1
2022
entrez:
31
10
2019
Statut:
ppublish
Résumé
Bipolar Disorder is costly and debilitating, and many treatments have side effects. Transcranial Direct Current Stimulation (tDCS) is a well-tolerated neuromodulation technique that may be a useful treatment for Bipolar Disorder if targeted to neural regions implicated in the disorder. One potential region is the left ventrolateral prefrontal cortex (vlPFC), which shows abnormally elevated activity during reward expectancy in individuals with Bipolar Disorder. We used a counterbalanced repeated measures design to assess the impact of cathodal (inhibitory) tDCS over the left vlPFC on reward circuitry activity, functional connectivity, and affect in adults with Bipolar Disorder, as a step toward developing novel interventions for individuals with the disorder. -1mA cathodal tDCS was administered over the left vlPFC versus a control region, left somatosensory cortex, concurrently with neuroimaging. Affect was assessed pre and post scan in remitted Bipolar Disorder (n = 27) and age/gender-matched healthy (n = 31) adults. Relative to cathodal tDCS over the left somatosensory cortex, cathodal tDCS over the left vlPFC lowered reward expectancy-related left ventral striatal activity (F(1,51) = 9.61, p = 0.003), and was associated with lower negative affect post scan, controlling for pre-scan negative affect, (F(1,49) = 5.57, p = 0.02) in all participants. Acute cathodal tDCS over the left vlPFC relative to the left somatosensory cortex reduces reward expectancy-related activity and negative affect post tDCS. Build on these findings, future studies can determine whether chronic cathodal tDCS over the left vlPFC has sustained effects on mood in individuals with Bipolar Disorder, to guide new treatment developments for the disorder.
Identifiants
pubmed: 31664174
doi: 10.1038/s41380-019-0567-1
pii: 10.1038/s41380-019-0567-1
pmc: PMC7188575
mid: NIHMS1541326
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4137-4145Subventions
Organisme : NIMH NIH HHS
ID : K01 MH117290
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH108421
Pays : United States
Informations de copyright
© 2019. The Author(s), under exclusive licence to Springer Nature Limited.
Références
Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS, et al. Grand challenges in global mental health. Nature. 2011;475:27–30.
doi: 10.1038/475027a
Meyer B, Johnson SL, Carver CS. Exploring behavioral activation and inhibition sensitivities among college students at risk for bipolar spectrum symptomatology. J Psychopathol Behav Assess. 1999;21:275–92.
doi: 10.1023/A:1022119414440
Alloy LB, Abramson LY, Walshaw PD, Cogswell A, Grandin LD, Hughes ME, et al. Behavioral approach system and behavioral inhibition system sensitivities and bipolar spectrum disorders: prospective prediction of bipolar mood episodes. Bipolar Disord. 2008;10:310–22.
doi: 10.1111/j.1399-5618.2007.00547.x
Giovanelli A, Hoerger M, Johnson SL, Gruber J. Impulsive responses to positive mood and reward are related to mania risk. Cogn Emot. 2013;27:1091–104.
doi: 10.1080/02699931.2013.772048
Caseras X, Lawrence NS, Murphy K, Wise RG, Phillips ML. Ventral striatum activity in response to reward: differences between bipolar I and II disorders. Am J Psychiatry. 2013;170:533–41.
doi: 10.1176/appi.ajp.2012.12020169
Jimura K, Chushak MS, Braver TS. Impulsivity and self-control during intertemporal decision making linked to the neural dynamics of reward value representation. J Neurosci. 2013;33:344–57.
doi: 10.1523/JNEUROSCI.0919-12.2013
Kim SH, Yoon H, Kim H, Hamann S. Individual differences in sensitivity to reward and punishment and neural activity during reward and avoidance learning. Soc Cogn Affect Neurosci. 2015;10:1219–27.
doi: 10.1093/scan/nsv007
Singh MK, Kelley RG, Howe ME, Reiss AL, Gotlib IH, Chang KD. Reward processing in healthy offspring of parents with bipolar disorder. JAMA Psychiatry. 2014;71:1148–56.
doi: 10.1001/jamapsychiatry.2014.1031
Bermpohl F, Kahnt T, Dalanay U, Hägele C, Sajonz B, Wegner T, et al. Altered representation of expected value in the orbitofrontal cortex in mania. Hum Brain Mapp. 2010;31:958–69.
doi: 10.1002/hbm.20909
Chase HW, Fournier JC, Bertocci MA, Greenberg T, Aslam H, Stiffler R, et al. A pathway linking reward circuitry, impulsive sensation-seeking and risky decision-making in young adults: identifying neural markers for new interventions. Transl Psychiatry. 2017;7:e1096.
doi: 10.1038/tp.2017.60
Lee SW, O’Doherty JP, Shimojo S. Neural computations mediating one-shot learning in the human brain. PLoS Biol. 2015;13:e1002137.
doi: 10.1371/journal.pbio.1002137
Smith BJ, Monterosso JR, Wakslak CJ, Bechara A, Read SJ. A meta-analytical review of brain activity associated with intertemporal decisions: Evidence for an anterior-posterior tangibility axis. Neurosci Biobehav Rev. 2018;86:85–98.
doi: 10.1016/j.neubiorev.2018.01.005
Davidson RJ, Shackman AJ, Maxwell JS. Asymmetries in face and brain related to emotion. Trends Cogn Sci. 2004;8:389–91.
doi: 10.1016/j.tics.2004.07.006
Phillips ML, Swartz HA. A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research. Am J Psychiatry. 2014;171:829–43.
doi: 10.1176/appi.ajp.2014.13081008
Grabenhorst F, Rolls ET. Value, pleasure and choice in the ventral prefrontal cortex. Trends Cogn Sci. 2011;15:56–67.
doi: 10.1016/j.tics.2010.12.004
Paulus MP, Frank LR. Anterior cingulate activity modulates nonlinear decision weight function of uncertain prospects. Neuroimage. 2006;30:668–77.
doi: 10.1016/j.neuroimage.2005.09.061
Baxter MG, Murray EA. The amygdala and reward. Nat Rev Neurosci. 2002;3:563.
doi: 10.1038/nrn875
Weiss SA, Bikson M. Open questions on the mechanisms of neuromodulation with applied and endogenous electric fields. Front Hum Neurosci. 2014;8:227.
doi: 10.3389/fnhum.2014.00227
Bindman LJ, Lippold OC, Redfearn JW. The action of brief polarizing currents on the cerebral cortex of the rat (1) during current flow and (2) in the production of long-lasting after-effects. J Physiol. 1964;172:369–82.
doi: 10.1113/jphysiol.1964.sp007425
Bikson M, Name A, Rahman A. Origins of specificity during tDCS: anatomical, activity-selective, and input-bias mechanisms. Front Hum Neurosci. 2013;7:688.
doi: 10.3389/fnhum.2013.00688
Dondé C, Neufeld NH, Geoffroy PA. The impact of transcranial direct current stimulation (tdcs) on bipolar depression, mania, and euthymia: a systematic review of preliminary data. Psychiatri Q. 2018;89:855–67.
Loo CK, Alonzo A, Martin D, Mitchell PB, Galvez V, Sachdev P. Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial. Br J psychiatry. 2012;200:52–59.
doi: 10.1192/bjp.bp.111.097634
Galvez V, Alonzo A, Martin D, Mitchell PB, Sachdev P, Loo CK. Hypomania induction in a patient with bipolar II disorder by transcranial direct current stimulation (tDCS). J ECT. 2011;27:256–8.
doi: 10.1097/YCT.0b013e3182012b89
Bai S, Dokos S, Ho KA, Loo C. A computational modelling study of transcranial direct current stimulation montages used in depression. Neuroimage. 2014;87:332–44.
doi: 10.1016/j.neuroimage.2013.11.015
Arul-Anandam AP, Loo C, Mitchell P. Induction of hypomanic episode with transcranial direct current stimulation. J ECT. 2010;26:68–69.
doi: 10.1097/YCT.0b013e3181a744bf
Weber MJ, Messing SB, Rao H, Detre JA, Thompson-Schill SL. Prefrontal transcranial direct current stimulation alters activation and connectivity in cortical and subcortical reward systems: a tDCS-fMRI study. Hum Brain Mapp. 2014;35:3673–86.
doi: 10.1002/hbm.22429
Vergallito A, Riva P, Pisoni A, Lauro LJR. Modulation of negative emotions through anodal tDCS over the right ventrolateral prefrontal cortex. Neuropsychologia. 2018;119:128–35
Lang N, Nitsche MA, Paulus W, Rothwell JC, Lemon RN. Effects of transcranial direct current stimulation over the human motor cortex on corticospinal and transcallosal excitability. Exp Brain Res. 2004;156:439–43.
doi: 10.1007/s00221-003-1800-2
Batsikadze G, Moliadze V, Paulus W, Kuo MF, Nitsche MA. Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans. J Physiol. 2013;591(Pt 7):1987–2000.
doi: 10.1113/jphysiol.2012.249730
Wang Y, Hao Y, Zhou J, Fried PJ, Wang X, Zhang J et al. Direct current stimulation over the human sensorimotor cortex modulates the brain's hemodynamic response to tactile stimulation. Eur J Neurosci. 2015;42:1933–40.
Dmochowski JP, Datta A, Bikson M, Su Y, Parra LC. Optimized multi-electrode stimulation increases focality and intensity at target. J Neural Eng. 2011;8:046011.
doi: 10.1088/1741-2560/8/4/046011
Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol. 1988;54:1063.
doi: 10.1037/0022-3514.54.6.1063
Bertocci M, Bebko G, Mullin B, Langenecker S, Ladouceur C, Almeida J, et al. Abnormal anterior cingulate cortical activity during emotional n-back task performance distinguishes bipolar from unipolar depressed females. Psychol Med. 2012;42:1417–28.
doi: 10.1017/S003329171100242X
Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 2003;19:1233–9.
doi: 10.1016/S1053-8119(03)00169-1
McLaren DG, Ries ML, Xu G, Johnson SC. A generalized form of context-dependent psychophysiological interactions (gPPI): a comparison to standard approaches. Neuroimage. 2012;61:1277–86.
doi: 10.1016/j.neuroimage.2012.03.068
Narum SR. Beyond Bonferroni: less conservative analyses for conservation genetics. Conserv Genet. 2006;7:783–7.
doi: 10.1007/s10592-005-9056-y
IBM Corp. Released 2016. IBM SPSS Statistics for Windows, Version 24.0. Armonk, NY: IBM Corp.
Tibshirani R. Regression shrinkage and selection via the Lasso. J R Stat Soc Ser B (Methodol). 1996;58:267–88.
Fiori V, Kunz L, Kuhnke P, Marangolo P, Hartwigsen G. Transcranial direct current stimulation (tDCS) facilitates verb learning by altering effective connectivity in the healthy brain. Neuroimage. 2018;181:550–9.
doi: 10.1016/j.neuroimage.2018.07.040
Kessler SK, Turkeltaub PE, Benson JG, Hamilton RH. Differences in the experience of active and sham transcranial direct current stimulation. Brain Stimul. 2012;5:155–62.
doi: 10.1016/j.brs.2011.02.007