Neurochemical sex differences in adult ADHD patients: an MRS study.
ADHD
Anterior cingulate cortex
Cerebellum
Choline
MRS
Sex
Journal
Biology of sex differences
ISSN: 2042-6410
Titre abrégé: Biol Sex Differ
Pays: England
ID NLM: 101548963
Informations de publication
Date de publication:
29 10 2019
29 10 2019
Historique:
received:
02
02
2019
accepted:
30
08
2019
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
29
4
2020
Statut:
epublish
Résumé
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Relevant sex differences in symptomatology are discussed. This study compared brain neurometabolism in the anterior cingulate cortex (ACC) and left cerebellar hemisphere in age- and IQ-matched adult male (mADHD) and female (fADHD) ADHD patients. We studied 48 (ACC) and 42 (cerebellum) male/female pairs of stimulant-free patients with adult ADHD. Single voxel magnetic resonance spectroscopy (MRS) was used to investigate creatine (Cre), total choline (t-Cho), glutamate + glutamine (Glx), N-acetylaspartate, and myo-inositol. The mADHD and fADHD groups were compared using robust linear regression. The level of significance was corrected for multiple tests using the Benjamini-Hochberg approach. For the ACC, the signals of Cre (p = 0.008) and t-Cho (p = 0.004) showed significant effects of the age covariate as well as an interaction of sex and age (Cre: p = 0.033; t-Cho: p = 0.040). For the Glx signal, an interaction of sex and age could also be observed (p = 0.033). For cerebellar neurometabolites, the signals of t-Cho (p = 0.049) and Glx (p = 0.049) showed significant effects of the factor sex. This is the largest study yet to analyze sex differences in brain neurochemistry in adult patients with ADHD. Different age-dependent t-Cho signals in the ACC might be associated with delayed myelinization in mADHD. Further MRS studies in adult ADHD, accounting for possible sex effects, are warranted to validate the present findings.
Identifiants
pubmed: 31665071
doi: 10.1186/s13293-019-0264-4
pii: 10.1186/s13293-019-0264-4
pmc: PMC6821019
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
50Références
Acta Neurol Scand. 1995 May;91(5):335-45
pubmed: 7639062
Dtsch Arztebl Int. 2008 Apr;105(17):311-7
pubmed: 19629241
J Psychiatr Res. 2007 Dec;41(11):934-41
pubmed: 17303167
Psychiatry Res. 2001 Feb 28;106(1):47-57
pubmed: 11231099
JAMA Psychiatry. 2015 Dec;72(12):1199-210
pubmed: 26536057
Mol Autism. 2017 Mar 7;8:10
pubmed: 28316774
Atten Defic Hyperact Disord. 2014 Mar;6(1):35-47
pubmed: 24132867
Psychiatr Clin North Am. 2010 Jun;33(2):357-73
pubmed: 20385342
Mol Psychiatry. 2014 Dec;19(12):1251
pubmed: 25407610
NMR Biomed. 2001 Jun;14(4):260-4
pubmed: 11410943
Proc Biol Sci. 1999 Jul 7;266(1426):1375-9
pubmed: 10445292
Anat Rec. 2001 Apr;265(2):54-84
pubmed: 11323770
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Dec 12;32(8):1778-81
pubmed: 18817837
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19649-54
pubmed: 18024590
J Am Acad Child Adolesc Psychiatry. 1997 Aug;36(8):1036-45
pubmed: 9256583
J Am Acad Child Adolesc Psychiatry. 2003 Mar;42(3):303-10
pubmed: 12595783
Transl Psychiatry. 2017 Jan 10;7(1):e999
pubmed: 28072412
J Psychiatry Neurosci. 2016 Oct;41(6):422-430
pubmed: 27575717
J Atten Disord. 2012 Feb;16(2):109-17
pubmed: 21173428
Biol Psychiatry. 2016 Dec 15;80(12):905-915
pubmed: 26115789
J Clin Psychiatry. 2008 Feb;69(2):213-21
pubmed: 18211131
N Engl J Med. 2013 Nov 14;369(20):1935-44
pubmed: 24224626
Br J Psychiatry Suppl. 1999;(37):2-6
pubmed: 10211132
Ann N Y Acad Sci. 2010 Feb;1187:148-71
pubmed: 20201852
Neurosci Biobehav Rev. 2013 Sep;37(8):1692-701
pubmed: 23735885
J Abnorm Child Psychol. 1996 Oct;24(5):555-69
pubmed: 8956084
Am J Psychiatry. 1993 Jun;150(6):885-90
pubmed: 8494063
World J Biol Psychiatry. 2009;10(4 Pt 2):355-65
pubmed: 18609427
Front Neuroendocrinol. 2014 Aug;35(3):331-46
pubmed: 24680800
Atten Defic Hyperact Disord. 2017 Mar;9(1):47-65
pubmed: 27866355
Biol Psychiatry. 2012 Aug 1;72(3):191-7
pubmed: 22418014
Neurobiol Aging. 2005 May;26(5):665-72
pubmed: 15708441
Biol Psychiatry. 1999 Nov 15;46(10):1388-95
pubmed: 10578453
Evid Based Ment Health. 2018 Nov;21(4):173-176
pubmed: 30301823
Am J Psychiatry. 2005 Jun;162(6):1083-9
pubmed: 15930056
Eur Arch Psychiatry Clin Neurosci. 2006 Aug;256(5):311-9
pubmed: 16685602
Magn Reson Med. 1993 Dec;30(6):672-9
pubmed: 8139448
Nervenarzt. 2003 Oct;74(10):939-46
pubmed: 14655655
Nervenarzt. 2008 Jul;79(7):809-19
pubmed: 18542906
Atten Defic Hyperact Disord. 2010 Dec;2(4):203-12
pubmed: 21432607
Clin Psychol Rev. 2015 Aug;40:15-27
pubmed: 26046624
Front Behav Neurosci. 2015 Sep 28;9:242
pubmed: 26441572
Nervenarzt. 2002 Sep;73(9):830-8
pubmed: 12215873
Lancet. 2005 Jul 16-22;366(9481):237-48
pubmed: 16023516
Eur Psychiatry. 2019 Feb;56:14-34
pubmed: 30453134
J Psychiatr Res. 2008 Jun;42(7):587-95
pubmed: 17698080
J Atten Disord. 2019 Jul;23(9):1047-1058
pubmed: 28745107
Behav Brain Funct. 2006 Aug 23;2:30
pubmed: 16925830
Front Hum Neurosci. 2016 Aug 02;10:367
pubmed: 27531975
Biol Psychiatry. 2014 Sep 15;76(6):486-94
pubmed: 24768119
J Neuroophthalmol. 2005 Sep;25(3):217-26
pubmed: 16148633
Arch Gen Psychiatry. 2001 May;58(5):461-5
pubmed: 11343525
Neuroimage. 2005 Jul 1;26(3):839-51
pubmed: 15955494
J Atten Disord. 2002 Jan;5(3):143-54
pubmed: 11911007
Mol Psychiatry. 2014 Dec;19(12):1314-25
pubmed: 25048006
Eur J Radiol. 2008 Aug;67(2):218-29
pubmed: 18434059