TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.
Animals
Cell Adhesion Molecules, Neuronal
/ metabolism
Dendritic Spines
/ metabolism
Gene Knockdown Techniques
HEK293 Cells
HeLa Cells
Hippocampus
/ metabolism
Humans
Membrane Microdomains
/ metabolism
Mice, Inbred C57BL
Protein Binding
Pyramidal Cells
/ metabolism
Rats, Wistar
Synapses
/ metabolism
Tetraspanins
/ chemistry
TEMs
TSPAN5
clustering
dendritic spines
neuroligin-1
synapses
tetraspanin
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
29 10 2019
29 10 2019
Historique:
received:
16
04
2018
revised:
09
07
2019
accepted:
18
09
2019
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
26
9
2020
Statut:
ppublish
Résumé
Tetraspanins are a class of evolutionarily conserved transmembrane proteins with 33 members identified in mammals that have the ability to organize specific membrane domains, named tetraspanin-enriched microdomains (TEMs). Despite the relative abundance of different tetraspanins in the CNS, few studies have explored their role at synapses. Here, we investigate the function of TSPAN5, a member of the tetraspanin superfamily for which mRNA transcripts are found at high levels in the mouse brain. We demonstrate that TSPAN5 is localized in dendritic spines of pyramidal excitatory neurons and that TSPAN5 knockdown induces a dramatic decrease in spine number because of defects in the spine maturation process. Moreover, we show that TSPAN5 interacts with the postsynaptic adhesion molecule neuroligin-1, promoting its correct surface clustering. We propose that membrane compartmentalization by tetraspanins represents an additional mechanism for regulating excitatory synapses.
Identifiants
pubmed: 31665629
pii: S2211-1247(19)31239-2
doi: 10.1016/j.celrep.2019.09.051
pmc: PMC6899445
pii:
doi:
Substances chimiques
Cell Adhesion Molecules, Neuronal
0
TSPAN5 protein, human
0
Tetraspanins
0
neuroligin 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1130-1146.e8Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : UK Medical Research Council
Pays : International
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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