Antinuclear Antibody Tests.

Antibodies, Antinuclear / blood Autoimmune Diseases / diagnosis Fluorescent Antibody Technique, Indirect Humans Immunoassay
ANA Antinuclear antibodies Jo-1 RNP SS-A SS-B Scl70 Sm

Journal

Clinics in laboratory medicine
ISSN: 1557-9832
Titre abrégé: Clin Lab Med
Pays: United States
ID NLM: 8100174

Informations de publication

Date de publication:
12 2019
Historique:
entrez: 1 11 2019
pubmed: 2 11 2019
medline: 25 7 2020
Statut: ppublish

Résumé

The presence of antinuclear antibodies (ANAs), which include autoantibodies to extractable nuclear antigens (ENAs), in the sera of patients with connective tissue diseases provides useful immunologic and pathophysiologic insight into the nature of their disease. This article discusses the most commonly used diagnostic modalities for detecting and quantitating the presence of ANA: indirect immunofluorescence assay, enzyme-linked immunosorbent assay, and multiplex bead technology, which serve as useful screening tests. We also review testing for autoantibodies to ENAs, which are often helpful to confirm the diagnosis of a specific connective tissue disease.

Identifiants

DOI: 10.1016/j.cll.2019.07.001 PMID: 31668266
pubmed: 31668266
pii: S0272-2712(19)30054-X
doi: 10.1016/j.cll.2019.07.001
pii:
doi:

Substances chimiques

Antibodies, Antinuclear 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

513-524

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Morris Ling (M)

Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Cox 201, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, 55 Fruit Street, Cox 201, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Cox 201, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, 55 Fruit Street, Cox 201, Boston, MA 02114, USA. Electronic address: mling@mgh.harvard.edu.

Mandakolathur Murali (M)

Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Cox 201, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Cox 201, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, 55 Fruit Street, Cox 201, Boston, MA 02114, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Anticorps antinucléaires › Antinuclear Antibody Tests.
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Antinuclear Antibody Tests.
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Technique d'immunofluorescence › Technique d'immunofluorescence indirecte › Antinuclear Antibody Tests.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Antinuclear Antibody Tests.
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Antinuclear Antibody Tests.