Methamphetamine administration impairs behavior, memory and underlying signaling pathways in the hippocampus.
Animals
Behavior, Animal
/ drug effects
Central Nervous System Stimulants
/ administration & dosage
Disease Models, Animal
Gliosis
/ chemically induced
Hippocampus
/ drug effects
Long-Term Potentiation
/ drug effects
Male
Memory Disorders
/ chemically induced
Methamphetamine
/ administration & dosage
Rats
Rats, Sprague-Dawley
Signal Transduction
/ drug effects
Spatial Memory
/ drug effects
Synaptic Transmission
/ drug effects
Hippocampus
Methamphetamine
Neurotransmission
RNA-seq
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
03 02 2020
03 02 2020
Historique:
received:
22
08
2019
revised:
06
10
2019
accepted:
10
10
2019
pubmed:
2
11
2019
medline:
1
5
2021
entrez:
1
11
2019
Statut:
ppublish
Résumé
Methamphetamine (METH) is a strong psychostimulant drug which can essentially affect different brain regions. Hippocampus as one of main components of limbic system plays key roles in processing of short term, long term and spatial memory. Herein, we explored the changes in behavior, synaptic transmission and hippocampal volume along with gliosis following METH treatment. Besides, using genome-wide expression profiling, we applied a pathway-based approach to detect significantly dysregulated signaling pathways. In this regard, we found that METH administration interrupts spatial memory and long term potentiation (LTP). Additionally, stereological analysis revealed a significant alteration in hippocampal volume along with increased gliosis upon METH treatment. We also identified several signaling cascades chiefly related to synaptic transmission which were considerably interrupted in the hippocampus of METH-treated rats. Taken together, our data suggests a potential link between behavioral disruptions and dysregulated signaling pathways.
Identifiants
pubmed: 31669515
pii: S0166-4328(19)31295-1
doi: 10.1016/j.bbr.2019.112300
pii:
doi:
Substances chimiques
Central Nervous System Stimulants
0
Methamphetamine
44RAL3456C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112300Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.