Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics.


Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
12 03 2020
Historique:
pubmed: 2 11 2019
medline: 1 9 2020
entrez: 1 11 2019
Statut: ppublish

Résumé

Human African trypanosomiasis (HAT) is a neglected tropical disease caused by infection with either of two subspecies of the parasite

Identifiants

pubmed: 31670951
doi: 10.1021/acs.jmedchem.9b01506
pmc: PMC8329730
mid: NIHMS1728378
doi:

Substances chimiques

Indazoles 0
Oxazepines 0
Small Molecule Libraries 0
Trypanocidal Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2527-2546

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI114685
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124046
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI126296
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI127594
Pays : United States

Références

PLoS Negl Trop Dis. 2014 Oct 23;8(10):e3253
pubmed: 25340575
Lancet. 2018 Jan 13;391(10116):144-154
pubmed: 29113731
Bioorg Med Chem Lett. 2013 Nov 1;23(21):5992-6000
pubmed: 24054120
Lancet. 2017 Nov 25;390(10110):2397-2409
pubmed: 28673422
Chem Rev. 2014 Nov 26;114(22):11280-304
pubmed: 26443079
Bioorg Med Chem Lett. 2016 Jun 1;26(11):2569-76
pubmed: 27080183
ACS Chem Neurosci. 2010 Jun 16;1(6):435-49
pubmed: 22778837

Auteurs

Dana M Klug (DM)

Department of Chemistry & Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States.

Laura Tschiegg (L)

Department of Chemistry & Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States.

Rosario Diaz (R)

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain.

Domingo Rojas-Barros (D)

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain.

Guiomar Perez-Moreno (G)

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain.

Gloria Ceballos (G)

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain.

Raquel García-Hernández (R)

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain.

Maria Santos Martinez-Martinez (MS)

Diseases of the Developing World (DDW), Tres Cantos Medicines Development Campus, GlaxoSmithKline, Tres Cantos 28760, Spain.

Pilar Manzano (P)

Diseases of the Developing World (DDW), Tres Cantos Medicines Development Campus, GlaxoSmithKline, Tres Cantos 28760, Spain.

Luis Miguel Ruiz (LM)

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain.

Conor R Caffrey (CR)

Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.

Francisco Gamarro (F)

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain.

Dolores Gonzalez Pacanowska (DG)

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain.

Lori Ferrins (L)

Department of Chemistry & Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States.

Miguel Navarro (M)

Instituto de Parasitología y Biomedicina "López-Neyra", Consejo Superior de Investigaciones Cientificas (CSIC), Granada 18016, Spain.

Michael P Pollastri (MP)

Department of Chemistry & Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH