CSF β-amyloid predicts early cerebellar atrophy and is associated with a poor prognosis in multiple sclerosis.
Adult
Amyloid beta-Peptides
/ cerebrospinal fluid
Atrophy
/ pathology
Cerebellum
/ diagnostic imaging
Disease Progression
Female
Follow-Up Studies
Gray Matter
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting
/ cerebrospinal fluid
Prognosis
Severity of Illness Index
Cerebellum
Multiple sclerosis
Progression
β-amyloid
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
30
05
2019
revised:
17
10
2019
accepted:
20
10
2019
pubmed:
2
11
2019
medline:
20
11
2020
entrez:
1
11
2019
Statut:
ppublish
Résumé
Neurodegeneration is present from the earliest stages of multiple sclerosis (MS) and is critically involved in MS related clinical disability. Aim of the present study was to assess the connection between amyloid burden and early cerebellar grey matter (GM) atrophy compared to early brain GM atrophy in MS patients. Forty newly diagnosed relapsing-remitting (RR-) MS patients were recruited. β-amyloid1-42 (Aβ) levels were determined in cerebrospinal fluid (CSF) samples from all subjects. All participants underwent neurological examination and brain magnetic resonance imaging (MRI) at baseline. Twenty-nine out of 40 patients repeated a brain MRI at 1-year follow-up. T1-weighted scans were segmented using the Voxel-Based Morphometry (VBM) protocol and the Spatially Unbiased Infratentorial Toolbox (SUIT) from Statistical Parametric Mapping (SPM12). Between-group comparison of cerebellar parenchymal fraction (GM+WM/total cerebellar volume%) showed significant differences between Aβ Early cerebellar atrophy seems to be crucial in predicting a poor prognosis in MS, more than early global brain atrophy.
Sections du résumé
BACKGROUND
BACKGROUND
Neurodegeneration is present from the earliest stages of multiple sclerosis (MS) and is critically involved in MS related clinical disability. Aim of the present study was to assess the connection between amyloid burden and early cerebellar grey matter (GM) atrophy compared to early brain GM atrophy in MS patients.
METHODS
METHODS
Forty newly diagnosed relapsing-remitting (RR-) MS patients were recruited. β-amyloid1-42 (Aβ) levels were determined in cerebrospinal fluid (CSF) samples from all subjects. All participants underwent neurological examination and brain magnetic resonance imaging (MRI) at baseline. Twenty-nine out of 40 patients repeated a brain MRI at 1-year follow-up. T1-weighted scans were segmented using the Voxel-Based Morphometry (VBM) protocol and the Spatially Unbiased Infratentorial Toolbox (SUIT) from Statistical Parametric Mapping (SPM12).
RESULTS
RESULTS
Between-group comparison of cerebellar parenchymal fraction (GM+WM/total cerebellar volume%) showed significant differences between Aβ
CONCLUSIONS
CONCLUSIONS
Early cerebellar atrophy seems to be crucial in predicting a poor prognosis in MS, more than early global brain atrophy.
Identifiants
pubmed: 31671315
pii: S2211-0348(19)30451-1
doi: 10.1016/j.msard.2019.101462
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101462Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflict of interest.