Epstein-Barr virus is absent in gastric superficial neoplastic lesions.
EBVaGC
Epstein-Barr virus (EBV)
Gastric cancer
Gastric dysplasia
Neoplastic lesion
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
16
04
2019
accepted:
22
09
2019
revised:
19
09
2019
pubmed:
2
11
2019
medline:
21
12
2019
entrez:
2
11
2019
Statut:
ppublish
Résumé
Epstein-Barr virus (EBV) has been associated with about 9% of all gastric carcinomas, but its role in gastric carcinogenesis remains unclear since there is lack of evidence of EBV presence in pre-neoplastic lesions of gastric mucosa. This study intends to determine the prevalence of EBV in gastric dysplasia and superficial neoplasia to clarify whether EBV infection is an early or late event in gastric cancer development. This retrospective study included a total of 242 gastric lesions from 199 consecutive patients who were referred for endoscopic resection. The histological classification of lesions includes 137 low- and high-grade dysplasia and 105 superficial carcinomas. EBV infection was investigated by EBER-ISH. Results showed that EBV was not detected in any epithelial cells of any case with dysplasia or superficial carcinomas, although we observed the presence of a small number of EBV-infected lymphocytes in 2.1% of all lesions. These results showed that EBV is not present in gastric dysplasia neither in superficial carcinomas suggesting that EBV carcinogenesis is a late event in well/moderately differentiated gastric carcinogenesis.
Identifiants
pubmed: 31673776
doi: 10.1007/s00428-019-02670-1
pii: 10.1007/s00428-019-02670-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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