Emerging Insights on the Interaction Between Anticancer and Immunosuppressant Drugs and Intestinal Microbiota in Pediatric Patients.
Animals
Anti-Bacterial Agents
/ administration & dosage
Antineoplastic Combined Chemotherapy Protocols
/ pharmacology
Arthritis, Juvenile
/ drug therapy
Bacterial Translocation
/ drug effects
Child
Clinical Trials as Topic
Disease Models, Animal
Disease Susceptibility
/ immunology
Drug Resistance
/ immunology
Gastrointestinal Microbiome
/ immunology
Host Microbial Interactions
/ immunology
Humans
Immunosuppressive Agents
/ pharmacology
Inflammatory Bowel Diseases
/ drug therapy
Intestinal Mucosa
/ drug effects
Mice
Permeability
/ drug effects
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ drug therapy
Specific Pathogen-Free Organisms
/ immunology
Symbiosis
/ drug effects
Treatment Outcome
Journal
Clinical and translational science
ISSN: 1752-8062
Titre abrégé: Clin Transl Sci
Pays: United States
ID NLM: 101474067
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
23
07
2019
accepted:
23
10
2019
pubmed:
2
11
2019
medline:
16
6
2021
entrez:
2
11
2019
Statut:
ppublish
Résumé
Diseases affecting the immune system, such as inflammatory bowel disease (IBD), juvenile idiopathic arthritis (JIA), and acute lymphoblastic leukemia (ALL), are pathological conditions affecting the pediatric population and are often associated with alterations in the intestinal microbiota, such as a decrease in bacterial diversity. Growing evidence suggests that gut microbiota can interfere with chemotherapeutic and immunosuppressant drugs, used in the treatment of these diseases, reducing or facilitating drug efficacy. In particular, the effect of intestinal microflora through translocation, immunomodulation, metabolism, enzymatic degradation, and reduction of bacterial diversity seems to be one of the reasons of interindividual variability in the therapeutic response. Although the extent of the role of intestinal microflora in chemotherapy and immunosuppression remains still unresolved, current evidence on bacterial compositional shifts will be taken in consideration together with clinical response to drugs for a better and personalized therapy. This review is focused on the effect of the intestinal microbiota on the efficacy of pharmacological therapy of agents used to treat IBD, JIA, and ALL.
Identifiants
pubmed: 31675176
doi: 10.1111/cts.12722
pmc: PMC7070880
doi:
Substances chimiques
Anti-Bacterial Agents
0
Immunosuppressive Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
238-259Informations de copyright
© 2019 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.
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