Use of nucleoside phosphorylases for the preparation of 5-modified pyrimidine ribonucleosides.

Bacterial Proteins / chemistry Catalysis Escherichia coli / enzymology Glycosylation Pentosyltransferases / chemistry Recombinant Proteins / chemistry Ribonucleosides / chemistry Uridine / chemistry
Enzymes Nucleoside phosphorylases Nucleosides Phosphorolysis Transglycosylation Uridine

Journal

Biochimica et biophysica acta. Proteins and proteomics
ISSN: 1878-1454
Titre abrégé: Biochim Biophys Acta Proteins Proteom
Pays: Netherlands
ID NLM: 101731734

Informations de publication

Date de publication:
01 2020
Historique:
received: 24 07 2019
revised: 25 09 2019
accepted: 06 10 2019
pubmed: 5 11 2019
medline: 4 3 2020
entrez: 3 11 2019
Statut: ppublish

Résumé

Enzymatic transglycosylation, a transfer of the carbohydrate moiety from one heterocyclic base to another, is catalyzed by nucleoside phosphorylases (NPs) and is being actively developed and applied for the synthesis of biologically important nucleosides. Here, we report an efficient one-step synthesis of 5-substitited pyrimidine ribonucleosides starting from 7-methylguanosine hydroiodide in the presence of nucleoside phosphorylases (NPs).

Identifiants

DOI: 10.1016/j.bbapap.2019.140292 PMID: 31676450
pubmed: 31676450
pii: S1570-9639(19)30178-5
doi: 10.1016/j.bbapap.2019.140292
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Recombinant Proteins 0
Ribonucleosides 0
Pentosyltransferases EC 2.4.2.-
nucleoside phosphorylase EC 2.4.2.-
Uridine WHI7HQ7H85

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

140292

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Cyril S Alexeev (CS)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow 119991, Russia.

Mikhail S Drenichev (MS)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow 119991, Russia.

Evgeniya O Dorinova (EO)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow 119991, Russia.

Roman S Esipov (RS)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya str. 16/10, Moscow 117997, Russia.

Irina V Kulikova (IV)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow 119991, Russia.

Sergey N Mikhailov (SN)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow 119991, Russia. Electronic address: smikh@eimb.ru.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Use of nucleoside phosphorylases for the...
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Use of nucleoside phosphorylases for the...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Use of nucleoside phosphorylases for the...
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Glycosylation › Use of nucleoside phosphorylases for the...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › Use of nucleoside phosphorylases for the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Use of nucleoside phosphorylases for the...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Use of nucleoside phosphorylases for the...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Uridine › Use of nucleoside phosphorylases for the...