A pH-dependent bolt involving cytosine bases located in the lateral loops of antiparallel G-quadruplex structures within the SMARCA4 gene promotor.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
12
07
2019
accepted:
15
10
2019
entrez:
3
11
2019
pubmed:
5
11
2019
medline:
12
11
2020
Statut:
epublish
Résumé
Some lung and ovarian tumors are connected to the loss of expression of SMARCA4 gene. In its promoter region, a 44-nucleotides long guanine sequence prone to form G-quadruplex structures has been studied by means of spectroscopic techniques (circular dichroism, molecular absorption and nuclear magnetic resonance), size exclusion chromatography and multivariate analysis. The results have shown that the central 21-nucleotides long sequence comprising four guanine tracts of disparate length is able to fold into a pH-dependent ensemble of G-quadruplex structures. Based on acid-base titrations and melting experiments of wild and mutated sequences, the formation of a C·C
Identifiants
pubmed: 31676783
doi: 10.1038/s41598-019-52311-5
pii: 10.1038/s41598-019-52311-5
pmc: PMC6825181
doi:
Substances chimiques
Nuclear Proteins
0
Transcription Factors
0
Cytosine
8J337D1HZY
SMARCA4 protein, human
EC 3.6.1.-
DNA Helicases
EC 3.6.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15807Références
Anal Biochem. 2014 Dec 1;466:4-15
pubmed: 25159622
Biochemistry. 2002 Dec 17;41(50):15017-24
pubmed: 12475251
Nucleic Acids Res. 2005 Sep 12;33(16):e138
pubmed: 16157860
J Am Chem Soc. 2004 Jan 14;126(1):165-9
pubmed: 14709080
Methods Enzymol. 1995;259:221-42
pubmed: 8538456
Trends Biotechnol. 2017 Oct;35(10):997-1013
pubmed: 28755976
Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1237-1245
pubmed: 27856299
Nucleic Acids Res. 2015 Oct 15;43(18):8627-37
pubmed: 26350216
Nucleic Acids Res. 2018 Nov 30;46(21):11605-11617
pubmed: 30277522
Angew Chem Int Ed Engl. 2019 Mar 4;58(10):2942-2957
pubmed: 30600876
J Inorg Biochem. 2017 Jan;166:190-198
pubmed: 27665315
Curr Opin Struct Biol. 2009 Jun;19(3):239-50
pubmed: 19487118
Curr Pharm Des. 2012;18(14):1880-99
pubmed: 22376104
Nat Rev Mol Cell Biol. 2017 May;18(5):279-284
pubmed: 28225080
Int J Biol Macromol. 2011 Nov 1;49(4):729-36
pubmed: 21777611
Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2165-2169
pubmed: 29266664
Biochimie. 2008 Jul;90(7):1040-51
pubmed: 18331845
PLoS One. 2010 Jul 19;5(7):e11647
pubmed: 20657837
Biochimie. 2017 Sep;140:20-33
pubmed: 28619677
Biochem Soc Trans. 2017 Oct 15;45(5):1173-1182
pubmed: 28939694
Nucleic Acids Res. 2008 Oct;36(17):5482-515
pubmed: 18718931
J Phys Chem B. 2009 Mar 5;113(9):2587-95
pubmed: 19014184
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W43-6
pubmed: 17452344
Nucleic Acids Res. 2010 Aug;38(14):4877-88
pubmed: 20348136
Chem Soc Rev. 2011 Nov;40(11):5293-307
pubmed: 21720638
Nucleic Acids Res. 2009 Apr;37(6):1713-25
pubmed: 19190094
Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1399-1413
pubmed: 28025083
Nat Genet. 2014 May;46(5):438-43
pubmed: 24658002
Nucleic Acids Res. 2014 Oct 29;42(19):e149
pubmed: 25143531
Nucleic Acids Res. 2003 Jul 1;31(13):3406-15
pubmed: 12824337
Nucleic Acids Res. 2018 May 4;46(8):4301-4315
pubmed: 29648656
Nat Chem. 2013 Mar;5(3):182-6
pubmed: 23422559
FEBS Lett. 2015 Jul 22;589(16):2117-23
pubmed: 26143373
Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1429-1447
pubmed: 27865995
Nucleic Acids Res. 2018 Sep 19;46(16):8038-8056
pubmed: 30124962
Nucleic Acids Res. 2019 Mar 18;47(5):2641-2653
pubmed: 30590801
Biopolymers. 2017 Jul;107(7):
pubmed: 28295161
Nucleic Acids Res. 2006 Feb 07;34(3):949-54
pubmed: 16464825
Biochimie. 2007 Dec;89(12):1562-72
pubmed: 17850948
J Am Chem Soc. 2017 Oct 11;139(40):13985-13988
pubmed: 28933543
Sci Rep. 2019 Feb 4;9(1):1210
pubmed: 30718769
Nucleic Acids Res. 1998 Jun 1;26(11):2679-85
pubmed: 9592154
J Biol Chem. 1995 Sep 29;270(39):23090-6
pubmed: 7559451
Nat Chem. 2018 Jun;10(6):631-637
pubmed: 29686376
Spectrochim Acta A Mol Biomol Spectrosc. 2018 May 5;196:185-195
pubmed: 29448171
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W676-82
pubmed: 16845096
FEBS J. 2014 Feb;281(4):1085-99
pubmed: 24304855
Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10645-8
pubmed: 21928459
Nucleic Acids Res. 2013 Sep;41(16):7934-46
pubmed: 23804761
Anal Biochem. 2006 Nov 1;358(1):76-89
pubmed: 16962983
Curr Protoc Nucleic Acid Chem. 2009 Jun;Chapter 17:17.1.1-17.1.15
pubmed: 19488970
Curr Protoc Nucleic Acid Chem. 2011 Jun;Chapter 17:Unit17.4
pubmed: 21638271