Long-Acting Growth Hormone Preparations - Current Status and Future Considerations.
adult
children
growth hormone deficiency
long acting growth hormone
treatment adherence
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
31
07
2019
accepted:
30
10
2019
pubmed:
5
11
2019
medline:
2
2
2021
entrez:
3
11
2019
Statut:
ppublish
Résumé
Long-acting GH (LAGH) preparations are currently being developed in an attempt to improve adherence. The profile of GH action following administration of LAGH raises practical questions about clinical monitoring and long-term safety and efficacy of these new therapeutic agents. Recent literature and meeting proceedings regarding LAGH preparations are reviewed. Multiple LAGH preparations are currently at various stages of development, allowing for decreased GH injection frequency from daily to weekly, biweekly, or monthly. Following administration of LAGH, the serum peak and trough GH and IGF-I levels vary depending upon the mechanism used to prolong GH action. Randomized, controlled clinical trials of some LAGH preparations have reported non-inferiority compared with daily recombinant human GH (rhGH) for improved growth velocity and body composition in children and adults with GH deficiency (GHD), respectively. No significant LAGH-related adverse events have been reported during short-term therapy. Multiple LAGH preparations are proceeding through clinical development with some showing promising evidence of short-term clinical efficacy and safety in children and adults with GHD. The relationship of transient elevations of GH and IGF-I following administration of LAGH to efficacy and safety remain to be elucidated. For LAGH to replace daily rhGH in the treatment of individuals with GHD, a number of practical questions need to be addressed including methods of dose adjustment, timing of monitoring of IGF-I, safety, efficacy, and cost-effectiveness. Long-term surveillance of efficacy and safety of LAGH preparations will be needed to answer these clinically relevant questions.
Identifiants
pubmed: 31676901
pii: 5611083
doi: 10.1210/clinem/dgz149
pmc: PMC7755139
pii:
doi:
Substances chimiques
Delayed-Action Preparations
0
Human Growth Hormone
12629-01-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : T32 DK065519
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Eur J Endocrinol. 2018 Sep;179(3):169-179
pubmed: 29973375
Eur J Endocrinol. 2015 Nov;173(5):541-51
pubmed: 26286586
PLoS One. 2011 Jan 31;6(1):e16223
pubmed: 21305004
Horm Res Paediatr. 2018;90(3):169-180
pubmed: 30199857
J Clin Endocrinol Metab. 2016 Mar;101(3):1091-7
pubmed: 26672637
Paediatr Drugs. 2013 Dec;15(6):427-9
pubmed: 24248475
Horm Res Paediatr. 2019;91(1):17-24
pubmed: 30947197
Eur J Endocrinol. 2015 Jun;172(6):779-90
pubmed: 25810462
Nat Med. 2007 Sep;13(9):1108-13
pubmed: 17721547
Arch Dis Child. 1979 Aug;54(8):609-13
pubmed: 507915
Diabetes Metab Syndr Obes. 2012;5:191-204
pubmed: 22826637
Clin Endocrinol (Oxf). 2016 Jun;84(6):862-9
pubmed: 26824335
Clin Pharmacol Drug Dev. 2017 Jul;6(4):331-342
pubmed: 27489211
J Clin Endocrinol Metab. 2019 Oct 1;104(10):4730-4742
pubmed: 31305924
J Clin Endocrinol Metab. 2011 Jun;96(6):1587-609
pubmed: 21602453
Horm Res Paediatr. 2017;87(5):324-332
pubmed: 28399519
Horm Res Paediatr. 2015;84(3):172-83
pubmed: 26227295
Nat Rev Cancer. 2008 Dec;8(12):915-28
pubmed: 19029956
J Clin Endocrinol Metab. 2001 Mar;86(3):1222-8
pubmed: 11238512
Endocr Pract. 2008 Mar;14(2):143-54
pubmed: 18308651
Horm Res Paediatr. 2018;90(1):54-63
pubmed: 29925064
Growth Horm IGF Res. 2015 Dec;25(6):286-93
pubmed: 26363846
J Pediatr Nurs. 2013 Jan;28(1):55-63
pubmed: 22300524
Endocrine. 2019 Jul;65(1):25-34
pubmed: 31119649
Front Endocrinol (Lausanne). 2019 Jun 28;10:416
pubmed: 31316468
Eur J Endocrinol. 2016 Feb;174(2):P1-9
pubmed: 26563978
Mol Pharm. 2012 Jul 2;9(7):2039-48
pubmed: 22663348
Biochem J. 1995 Dec 15;312 ( Pt 3):725-31
pubmed: 8554512
J Control Release. 2009 Jul 20;137(2):160-5
pubmed: 19332090
Clin Pharmacokinet. 2019 Jan;58(1):63-75
pubmed: 29671202
Int J Nanomedicine. 2014 Jul 25;9:3527-38
pubmed: 25114523
Pharm Res. 1997 Jun;14(6):730-5
pubmed: 9210189
Growth Horm IGF Res. 2015 Oct;25(5):201-6
pubmed: 26187188
Drug Des Devel Ther. 2015 Dec 18;10:13-21
pubmed: 26719670
Horm Res. 2006;65(1):6-13
pubmed: 16340214
J Med Chem. 2000 May 4;43(9):1664-9
pubmed: 10794683
Adv Pediatr. 2011;58(1):207-41
pubmed: 21736983
Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E1008-15
pubmed: 12376329
Eur J Endocrinol. 2016 Jun;174(6):C1-8
pubmed: 27009113
Acta Endocrinol (Copenh). 1983 Oct;104(2):148-52
pubmed: 6637329
Eur J Endocrinol. 2011 Sep;165(3):401-9
pubmed: 21724838
Adv Drug Deliv Rev. 2002 Jun 17;54(4):457-8
pubmed: 12052708
J Clin Endocrinol Metab. 2004 Jul;89(7):3234-40
pubmed: 15240597
J Clin Endocrinol Metab. 2016 May;101(5):2149-59
pubmed: 26918292
Eur J Endocrinol. 2017 Aug;177(2):195-205
pubmed: 28566441
Indian J Endocrinol Metab. 2012 Dec;16(Suppl 2):S178-84
pubmed: 23565373
Biotechnol Prog. 1998 Jan-Feb;14(1):108-15
pubmed: 9496675
Anat Rec A Discov Mol Cell Evol Biol. 2006 Jan;288(1):91-103
pubmed: 16342207
Pituitary. 2014 Oct;17(5):477-85
pubmed: 24122237
Eur J Endocrinol. 2017 Mar;176(3):283-294
pubmed: 27932411
J Clin Endocrinol Metab. 2006 Jun;91(6):2047-54
pubmed: 16537676
J Clin Endocrinol Metab. 2017 May 1;102(5):1673-1682
pubmed: 28201598
Growth Horm IGF Res. 2019 Feb;44:1-5
pubmed: 30414995
J Control Release. 2006 May 15;112(2):167-74
pubmed: 16542746
Clin Ther. 2008 Feb;30(2):307-16
pubmed: 18343269
Horm Res Paediatr. 2011;76 Suppl 1:33-8
pubmed: 21778746
Clin Endocrinol (Oxf). 2017 Oct;87(4):350-358
pubmed: 28656605
J Clin Endocrinol Metab. 2011 Jul;96(7):2255-61
pubmed: 21543424
Biomaterials. 2005 Sep;26(25):5259-66
pubmed: 15792553
Nat Med. 1996 Jul;2(7):795-9
pubmed: 8673926
Horm Res. 2007;68 Suppl 5:41-7
pubmed: 18174706
Neurology. 2014 Aug 26;83(9):780-6
pubmed: 25122206
Pharm Res. 1998 Feb;15(2):357-61
pubmed: 9523328
J Clin Endocrinol Metab. 2013 Jun;98(6):2595-603
pubmed: 23585663
Pediatr Endocrinol Rev. 2018 Dec;16(2):240-255
pubmed: 30556657
Mol Ther. 2019 Mar 6;27(3):673-680
pubmed: 30765323
Eur J Endocrinol. 2009 Mar;160(3):349-55
pubmed: 19074465
J Clin Endocrinol Metab. 2010 Jan;95(1):167-77
pubmed: 19906787
J Control Release. 2012 Jul 20;161(2):461-72
pubmed: 22094104
J Clin Endocrinol Metab. 2014 Jan;99(1):126-32
pubmed: 24170106
J Clin Endocrinol Metab. 2015 Jun;100(6):2192-203
pubmed: 25839904
Front Endocrinol (Lausanne). 2017 Nov 20;8:313
pubmed: 29209274
Growth Horm IGF Res. 2017 Aug;35:8-16
pubmed: 28595133
Endocr Connect. 2017 Nov;6(8):R171-R181
pubmed: 28947559
Eur J Endocrinol. 2018 May;178(5):491-499
pubmed: 29500310
J Med Chem. 2015 Sep 24;58(18):7370-80
pubmed: 26308095
J Clin Endocrinol Metab. 2012 Feb;97(2):E213-7
pubmed: 22238393
Int J Immunopathol Pharmacol. 2004 Jan-Apr;17(1):33-8
pubmed: 15000864
Clin Endocrinol (Oxf). 2015 Jul;83(1):85-90
pubmed: 25523467
J Clin Endocrinol Metab. 2012 Feb;97(2):416-25
pubmed: 22238382
J Clin Endocrinol Metab. 2012 Feb;97(2):400-7
pubmed: 22162481
PLoS One. 2018 Oct 24;13(10):e0206009
pubmed: 30356273
Nanoscale. 2013 May 21;5(10):4262-9
pubmed: 23546513
J Rheumatol. 1987 Aug;14(4):798-805
pubmed: 2822925
Eur J Endocrinol. 2009 Oct;161(4):533-40
pubmed: 19654233
J Clin Endocrinol Metab. 2011 Jun;96(6):1668-70
pubmed: 21602459
N Engl J Med. 2005 Aug 4;353(5):487-97
pubmed: 16079372
Horm Res Paediatr. 2018;90(4):221-227
pubmed: 30522126
Growth Horm IGF Res. 2018 Jun;40:61-68
pubmed: 29422321
J Pharm Sci. 2012 Aug;101(8):2744-54
pubmed: 22678811
J Pediatr Endocrinol Metab. 2002 May;15 Suppl 2:715-22
pubmed: 12092685
Clin Pharmacol Drug Dev. 2018 Jun;7(5):554-563
pubmed: 29136343
J Pediatr. 2010 Aug;157(2):265-70
pubmed: 20400105
J Clin Endocrinol Metab. 2017 May 1;102(5):1578-1587
pubmed: 28323965
J Clin Pharm Ther. 2018 Oct;43(5):640-646
pubmed: 29959799