Melatonin supplementation and pro-inflammatory mediators: a systematic review and meta-analysis of clinical trials.
C-Reactive protein
Inflammation
Interleukin-6
Melatonin
Meta-analysis
Tumor necrosis factor-α
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
11
06
2019
accepted:
21
10
2019
pubmed:
5
11
2019
medline:
24
6
2021
entrez:
4
11
2019
Statut:
ppublish
Résumé
Inflammatory processes are involved in chronic diseases. It has been suggested that melatonin reduces inflammation by its radical scavenging properties; however, the results of the previous studies are inconclusive. The objective of the present meta-analysis is to determine the direction and magnitude of melatonin supplementation effect on inflammatory biomarkers. Databases including PubMed, Scopus, Cochran Library, Embase, and Google Scholar were searched up to April 2019. Meta-analysis was performed using random-effect model. Subgroup analysis, sensitivity analysis, and meta-regression were also carried out. Thirteen eligible studies with 22 datasets with total sample size of 749 participants were included in the meta-analysis. Melatonin supplementation significantly decreased TNF-α and IL-6 levels [(WMD = - 2.24 pg/ml; 95% CI - 3.45, - 1.03; P < 0.001; I The results of the present meta-analysis support that melatonin supplementation could be effective on ameliorating of inflammatory mediators.
Sections du résumé
BACKGROUND
BACKGROUND
Inflammatory processes are involved in chronic diseases. It has been suggested that melatonin reduces inflammation by its radical scavenging properties; however, the results of the previous studies are inconclusive. The objective of the present meta-analysis is to determine the direction and magnitude of melatonin supplementation effect on inflammatory biomarkers.
METHODS
METHODS
Databases including PubMed, Scopus, Cochran Library, Embase, and Google Scholar were searched up to April 2019. Meta-analysis was performed using random-effect model. Subgroup analysis, sensitivity analysis, and meta-regression were also carried out.
RESULTS
RESULTS
Thirteen eligible studies with 22 datasets with total sample size of 749 participants were included in the meta-analysis. Melatonin supplementation significantly decreased TNF-α and IL-6 levels [(WMD = - 2.24 pg/ml; 95% CI - 3.45, - 1.03; P < 0.001; I
CONCLUSION
CONCLUSIONS
The results of the present meta-analysis support that melatonin supplementation could be effective on ameliorating of inflammatory mediators.
Identifiants
pubmed: 31679041
doi: 10.1007/s00394-019-02123-0
pii: 10.1007/s00394-019-02123-0
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
Interleukin-6
0
C-Reactive Protein
9007-41-4
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1803-1813Références
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