Investigation of anti-inflammatory and analgesic activities of camel milk in animal models.


Journal

Pakistan journal of pharmaceutical sciences
ISSN: 1011-601X
Titre abrégé: Pak J Pharm Sci
Pays: Pakistan
ID NLM: 9426356

Informations de publication

Date de publication:
Jul 2019
Historique:
entrez: 5 11 2019
pubmed: 5 11 2019
medline: 24 3 2020
Statut: ppublish

Résumé

Opioids and non-opioids have long been used as analgesic, anti-inflammatory and antipyretic. Long-term use of these drugs may lead to severe toxicities. Therefore natural remedies are now being explored to avoid risk of adverse effects associated with the use of these conventional medicines. Bioactive components from milk of different species have been identified as nutraceuticals, but no experimental or clinical study is conducted so far to explore the analgesic and anti-inflammatory potential of camel milk. In this study we evaluated camel milk for its possible analgesic and antiinflammatory activity. The anti-inflammatory effects of camel milk was studied in rats using paw edema method (induced by acetic acid) while tail-flick method was used to evaluate its analgesic effect in mice. Significantly increased tail-flick latency was shown after camel milk (33ml/kg) treatment when compared with acetylsalicylic acid at all time intervals. Anti-inflammatory activity of camel milk was significant (p<0.001) at 4th hour of treatment as shown by maximum percentage inhibition in edema volume (46.84%) in comparison to control. Results of our present study suggested possible use of camel milk as adjuvant therapy in treating various chronic pain and inflammatory ailments. Camel milk could further be investigated in future for recognition of biochemical constituents responsible for its antiinflammatory and pain relieving activities.

Identifiants

pubmed: 31680087

Substances chimiques

Analgesics 0
Anti-Inflammatory Agents 0
Antipyretics 0
Biological Products 0
Carrageenan 9000-07-1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1879-1883

Auteurs

Humera Khatoon (H)

Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan.

Rahila Ikram (R)

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan.

Humaira Anser (H)

Faculty of Pharmaceutical Sciences, Jinnah Sind Medical University, Karachi, Pakistan.

Sadaf Naeem (S)

Faculty of Pharmaceutical Sciences, Jinnah Sind Medical University, Karachi, Pakistan.

Saira Saeed Khan (SS)

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan.

Sakina Fatima (S)

Department of Pharmaceutics, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan.

Nuzhat Sultana (N)

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan.

Sana Sarfaraz (S)

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan.

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Classifications MeSH