Investigation of anti-inflammatory and analgesic activities of camel milk in animal models.
Analgesics
/ pharmacology
Animals
Anti-Inflammatory Agents
/ pharmacology
Antipyretics
/ pharmacology
Biological Products
/ pharmacology
Camelus
/ metabolism
Carrageenan
/ pharmacology
Edema
/ chemically induced
Female
Fever
/ chemically induced
Male
Mice
Milk
/ metabolism
Models, Animal
Pain
/ chemically induced
Rats
Journal
Pakistan journal of pharmaceutical sciences
ISSN: 1011-601X
Titre abrégé: Pak J Pharm Sci
Pays: Pakistan
ID NLM: 9426356
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
entrez:
5
11
2019
pubmed:
5
11
2019
medline:
24
3
2020
Statut:
ppublish
Résumé
Opioids and non-opioids have long been used as analgesic, anti-inflammatory and antipyretic. Long-term use of these drugs may lead to severe toxicities. Therefore natural remedies are now being explored to avoid risk of adverse effects associated with the use of these conventional medicines. Bioactive components from milk of different species have been identified as nutraceuticals, but no experimental or clinical study is conducted so far to explore the analgesic and anti-inflammatory potential of camel milk. In this study we evaluated camel milk for its possible analgesic and antiinflammatory activity. The anti-inflammatory effects of camel milk was studied in rats using paw edema method (induced by acetic acid) while tail-flick method was used to evaluate its analgesic effect in mice. Significantly increased tail-flick latency was shown after camel milk (33ml/kg) treatment when compared with acetylsalicylic acid at all time intervals. Anti-inflammatory activity of camel milk was significant (p<0.001) at 4th hour of treatment as shown by maximum percentage inhibition in edema volume (46.84%) in comparison to control. Results of our present study suggested possible use of camel milk as adjuvant therapy in treating various chronic pain and inflammatory ailments. Camel milk could further be investigated in future for recognition of biochemical constituents responsible for its antiinflammatory and pain relieving activities.
Substances chimiques
Analgesics
0
Anti-Inflammatory Agents
0
Antipyretics
0
Biological Products
0
Carrageenan
9000-07-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM