Evaluation of white matter microstructure in patients with Parkinson's disease using microscopic fractional anisotropy.
Anterior corona radiata
Diffusion tensor imaging
Microscopic fractional anisotropy
Parkinson’s disease
Journal
Neuroradiology
ISSN: 1432-1920
Titre abrégé: Neuroradiology
Pays: Germany
ID NLM: 1302751
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
16
04
2019
accepted:
03
10
2019
pubmed:
5
11
2019
medline:
18
11
2020
entrez:
5
11
2019
Statut:
ppublish
Résumé
Micro fractional anisotropy (μFA) is more accurate than conventional fractional anisotropy (FA) for assessing microscopic tissue properties and can overcome limitations related to crossing white matter fibres. We compared μFA and FA for evaluating white matter changes in patients with Parkinson's disease (PD). We compared FA and μFA measures between 25 patients with PD and 25 age- and gender-matched healthy controls using tract-based spatial statistics (TBSS) analysis. We also examined potential correlations between changes, revealed by conventional FA or μFA, and disease duration or Unified Parkinson's Disease Rating Scale (UPDRS)-III scores. Compared with healthy controls, patients with PD had significantly reduced μFA values, mainly in the anterior corona radiata (ACR). In the PD group, μFA values (primarily those from the ACR) were significantly negatively correlated with UPDRS-III motor scores. No significant changes or correlations with disease duration or UPDRS-III scores with tissue properties were detected using conventional FA. μFA can evaluate microstructural changes that occur during white matter degeneration in patients with PD and may overcome a key limitation of FA.
Identifiants
pubmed: 31680195
doi: 10.1007/s00234-019-02301-1
pii: 10.1007/s00234-019-02301-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
197-203Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP19dm0307024
Organisme : Japan Society for the Promotion of Science
ID : JP16K19854
Organisme : Ministry of Education, Culture, Sports, Science and Technology (JP)
ID : a High Technology Research Centre Grant
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : Programme for the Private University Research Branding Project
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