Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations.
ABC
B cells
Breg
DN2
atypical B cells
memory
naïve
transitional
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
07
2019
accepted:
01
10
2019
entrez:
5
11
2019
pubmed:
5
11
2019
medline:
18
11
2020
Statut:
epublish
Résumé
The increasingly recognized role of different types of B cells and plasma cells in protective and pathogenic immune responses combined with technological advances have generated a plethora of information regarding the heterogeneity of this human immune compartment. Unfortunately, the lack of a consistent classification of human B cells also creates significant imprecision on the adjudication of different phenotypes to well-defined populations. Additional confusion in the field stems from: the use of non-discriminatory, overlapping markers to define some populations, the extrapolation of mouse concepts to humans, and the assignation of functional significance to populations often defined by insufficient surface markers. In this review, we shall discuss the current understanding of human B cell heterogeneity and define major parental populations and associated subsets while discussing their functional significance. We shall also identify current challenges and opportunities. It stands to reason that a unified approach will not only permit comparison of separate studies but also improve our ability to define deviations from normative values and to create a clean framework for the identification, functional significance, and disease association with new populations.
Identifiants
pubmed: 31681331
doi: 10.3389/fimmu.2019.02458
pmc: PMC6813733
doi:
Substances chimiques
Cytokines
0
Immunoglobulin D
0
Immunoglobulin M
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2458Subventions
Organisme : NIAID NIH HHS
ID : U19 AI109962
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007656
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI121252
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI125180
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI110483
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI141993
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI049660
Pays : United States
Informations de copyright
Copyright © 2019 Sanz, Wei, Jenks, Cashman, Tipton, Woodruff, Hom and Lee.
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