Characterisation of One Class of Group III Sensory Neurons Innervating Abdominal Muscles of the Mouse.
Abdominal Muscles
/ innervation
Animals
Axons
/ metabolism
Capsaicin
/ pharmacology
Mechanoreceptors
/ physiology
Mice
Mice, Inbred C57BL
Muscle, Skeletal
Neural Conduction
/ physiology
Neurons, Afferent
/ physiology
Physical Stimulation
Sensory Receptor Cells
/ physiology
Sensory Thresholds
/ physiology
Chemosensitivity
Group III
Mechanosensitivity
Metabolites
Muscle afferents
Sensory
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
21 11 2019
21 11 2019
Historique:
received:
16
05
2019
revised:
11
09
2019
accepted:
12
09
2019
pubmed:
5
11
2019
medline:
2
10
2020
entrez:
5
11
2019
Statut:
ppublish
Résumé
Group III/IV striated muscle afferents are small diameter sensory neurons that play important roles in reflexes and sensation. To date, the morphological features of physiologically characterised group III/IV muscular afferents have not been identified. Here, the electrophysiological and morphological characteristics of sensory neurons innervating striated muscles of the mouse abdominal wall were investigated, ex vivo. Extracellular recordings were made from subcostal nerve trunks innervating the muscles. A distinctive class of mechanosensitive afferents was identified by a combination of physiological features including sensitivity to local compression, saturating response to graded stretch and, in most cases, absence of spontaneous firing. Studies were restricted to these distinctive units. These units had conduction velocities averaging 14 ± 4 m/s (range: 8-20 m/s, n = 7); within the range of group III fibres in mice. Von Frey hairs were used to map receptive fields, which covered an area of 0.36 ± 0.18 mm
Identifiants
pubmed: 31682818
pii: S0306-4522(19)30664-5
doi: 10.1016/j.neuroscience.2019.09.019
pii:
doi:
Substances chimiques
Capsaicin
S07O44R1ZM
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-175Informations de copyright
Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.