Infections caused by naturally AmpC-producing Enterobacteriaceae: Can we use third-generation cephalosporins? A narrative review.

Anti-Bacterial Agents / pharmacology Bacterial Proteins / biosynthesis Cephalosporins / pharmacology Colony Count, Microbial Drug Resistance, Bacterial Enterobacteriaceae / classification Enterobacteriaceae Infections / drug therapy beta-Lactamases / biosynthesis
AmpC Antibiotic therapy Cephalosporinase Enterobacteriaceae

Journal

International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860

Informations de publication

Date de publication:
Feb 2020
Historique:
received: 17 03 2019
revised: 07 10 2019
accepted: 20 10 2019
pubmed: 5 11 2019
medline: 24 11 2020
entrez: 5 11 2019
Statut: ppublish

Résumé

The burden of antibiotic-resistant infections among Gram-negative bacteria is increasing. Resistance to third-generation cephalosporins (3GCs) in Enterobacteriaceae is mainly conferred by the acquisition of β-lactamases or by deregulation of natural genetically-encoded β-lactamase enzymes. Enterobacteriaceae such as Enterobacter spp., Serratia marcescens, Citrobacter freundii, Providencia spp. and Morganella morganii (ESCPM group) possess chromosomally-encoded inducible AmpC β-lactamases. AmpC can be overproduced as a response to β-lactam antibiotic exposure or by constitutive dysfunction of the AmpC regulation system. This overproduction can lead to the inactivation of 3GCs. Based on small clinical studies, international guidelines and expert recommendations suggest that 3GCs should be avoided as definitive therapy for infections caused by ESCPM group organisms. In this narrative review, we discuss the published literature and evaluate the risk related to 3GC use in the case of documented ESCPM infection.

Identifiants

DOI: 10.1016/j.ijantimicag.2019.10.015 PMID: 31682902
pubmed: 31682902
pii: S0924-8579(19)30295-X
doi: 10.1016/j.ijantimicag.2019.10.015
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0
Cephalosporins 0
AmpC beta-lactamases EC 3.5.2.6
beta-Lactamases EC 3.5.2.6

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

105834

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

A Mizrahi (A)

Service de microbiologie clinique et dosage des anti-infectieux, Groupe Hospitalier Paris Saint Joseph, 75014 Paris, France; EA4043 Unité Bactéries Pathogènes et Santé, Université Paris-Sud Saclay, Chatenay-Malabry, France. Electronic address: amizrahi@hpsj.fr.

T Delerue (T)

Laboratoire Bactériologie-Virologie-Hygiène, Hôpital Avicenne, Université Paris 13, 93000 Bobigny, France.

H Morel (H)

Laboratoire Bactériologie-Virologie-Hygiène, Hôpital Avicenne, Université Paris 13, 93000 Bobigny, France.

A Le Monnier (A)

Service de microbiologie clinique et dosage des anti-infectieux, Groupe Hospitalier Paris Saint Joseph, 75014 Paris, France; EA4043 Unité Bactéries Pathogènes et Santé, Université Paris-Sud Saclay, Chatenay-Malabry, France.

E Carbonnelle (E)

Laboratoire Bactériologie-Virologie-Hygiène, Hôpital Avicenne, Université Paris 13, 93000 Bobigny, France; UMR 1137 IAME, INSERM, Université Paris 13, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

B Pilmis (B)

Equipe mobile de microbiologie clinique, Groupe Hospitalier Paris Saint Joseph, 75014 Paris, France.

J R Zahar (JR)

Laboratoire Bactériologie-Virologie-Hygiène, Hôpital Avicenne, Université Paris 13, 93000 Bobigny, France; UMR 1137 IAME, INSERM, Université Paris 13, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Infections caused by naturally AmpC-producing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Infections caused by naturally AmpC-producing...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Infections caused by naturally AmpC-producing...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Techniques microbiologiques › Numération de colonies microbiennes › Infections caused by naturally AmpC-producing...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Infections caused by naturally AmpC-producing...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Infections caused by naturally AmpC-producing...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections caused by naturally AmpC-producing...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Infections caused by naturally AmpC-producing...