Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort.
Advanced glycosylation
Biomarker
Disability
Physical function
Journal
BMC geriatrics
ISSN: 1471-2318
Titre abrégé: BMC Geriatr
Pays: England
ID NLM: 100968548
Informations de publication
Date de publication:
04 11 2019
04 11 2019
Historique:
received:
15
04
2019
accepted:
17
10
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
25
7
2020
Statut:
epublish
Résumé
Advanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent studies suggested that the ratio of AGEs and their soluble receptor (sRAGE) is a more accurate biomarker for age-related diseases than each separately. We aim to investigate whether this also applies for physical functioning in a broad age-spectrum. AGE and sRAGE levels, and physical functioning (SF-12 questionnaire) of 967 men and 812 women (45-83 years) were measured in the CARLA study. We used ordinal logistic regression to examine associations between AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning in sex- and age-stratified models. Higher levels of AGEs and AGE/sRAGE ratio were associated with lower physical functioning only in women, even after consideration of classical lifestyle and age-related factors (education, BMI, smoking, alcohol consumption, diet, creatinine clearance, diabetes mellitus, lipid lowering and antihypertensive drugs) (odds ratio (OR) =0.86, 95%confidence interval = 0.74-0.98 and OR = 0.86, 95%CI = 0.75-0.98 for AGEs and AGE/sRAGE ratio respectively). We could not demonstrate a significant difference across age. We showed a sex-specific association between physical functioning and AGEs and AGE/sRAGE, but no stronger associations of the latter with physical functioning. Further investigation is needed in the pathophysiology of this association.
Sections du résumé
BACKGROUND
Advanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent studies suggested that the ratio of AGEs and their soluble receptor (sRAGE) is a more accurate biomarker for age-related diseases than each separately. We aim to investigate whether this also applies for physical functioning in a broad age-spectrum.
METHODS
AGE and sRAGE levels, and physical functioning (SF-12 questionnaire) of 967 men and 812 women (45-83 years) were measured in the CARLA study. We used ordinal logistic regression to examine associations between AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning in sex- and age-stratified models.
RESULTS
Higher levels of AGEs and AGE/sRAGE ratio were associated with lower physical functioning only in women, even after consideration of classical lifestyle and age-related factors (education, BMI, smoking, alcohol consumption, diet, creatinine clearance, diabetes mellitus, lipid lowering and antihypertensive drugs) (odds ratio (OR) =0.86, 95%confidence interval = 0.74-0.98 and OR = 0.86, 95%CI = 0.75-0.98 for AGEs and AGE/sRAGE ratio respectively). We could not demonstrate a significant difference across age.
CONCLUSIONS
We showed a sex-specific association between physical functioning and AGEs and AGE/sRAGE, but no stronger associations of the latter with physical functioning. Further investigation is needed in the pathophysiology of this association.
Identifiants
pubmed: 31684879
doi: 10.1186/s12877-019-1323-8
pii: 10.1186/s12877-019-1323-8
pmc: PMC6829799
doi:
Substances chimiques
Biomarkers
0
Glycation End Products, Advanced
0
Receptor for Advanced Glycation End Products
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
299Références
Int J Angiol. 2018 Mar;27(1):1-12
pubmed: 29483760
Age Ageing. 2016 Nov;45(6):819-826
pubmed: 27515676
Diabetes Care. 2015 Jan;38(1):119-25
pubmed: 25336748
Rheumatology (Oxford). 2009 Oct;48(10):1190-6
pubmed: 19589888
Med Care. 1996 Mar;34(3):220-33
pubmed: 8628042
Biol Chem. 2008 Mar;389(3):257-65
pubmed: 18208349
J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1545-1551
pubmed: 29718128
Cell. 1999 Jun 25;97(7):889-901
pubmed: 10399917
Mol Med. 2007 Nov-Dec;13(11-12):625-35
pubmed: 17932553
Dtsch Arztebl Int. 2016 Oct 21;113(42):704-711
pubmed: 27866565
J Gerontol A Biol Sci Med Sci. 2010 Sep;65(9):963-75
pubmed: 20478906
Cell Metab. 2018 Sep 4;28(3):337-352
pubmed: 30184484
J Bone Miner Res. 2018 Mar;33(3):437-448
pubmed: 29160901
Mol Cell Biochem. 2016 Dec;423(1-2):105-114
pubmed: 27714575
Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):815-20
pubmed: 15692098
Diabetologia. 2004 Jul;47(7):1324-1330
pubmed: 15243705
Am J Clin Nutr. 1999 Oct;70(4):439-47
pubmed: 10500011
Z Gerontol Geriatr. 2007 Oct;40(5):349-56
pubmed: 17943238
Int J Angiol. 2015 Jun;24(2):75-80
pubmed: 26060376
BMC Cardiovasc Disord. 2005 Nov 11;5:33
pubmed: 16283930
Mol Med. 2011 Sep-Oct;17(9-10):980-9
pubmed: 21629968
BMJ. 2009 Jun 29;338:b2393
pubmed: 19564179
Eur J Clin Chem Clin Biochem. 1997 Sep;35(9):669-77
pubmed: 9352229
PLoS One. 2017 Sep 6;12(9):e0184019
pubmed: 28877202
J Proteomics. 2013 Oct 30;92:248-59
pubmed: 23702329
Mol Cell Biochem. 2016 Mar;414(1-2):171-8
pubmed: 26895319
Nephron. 1976;16(1):31-41
pubmed: 1244564
J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):710-6
pubmed: 24127427
J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):226-232
pubmed: 29529179
BMC Geriatr. 2017 Oct 25;17(1):247
pubmed: 29070027
Int J Cardiol. 2012 Jul 26;158(3):461-2
pubmed: 22652038
Clin Nutr. 2018 Jun;37(3):919-925
pubmed: 29381139
Eur J Appl Physiol. 2010 Jan;108(1):191-5
pubmed: 19756703
Clin Chim Acta. 2006 Sep;371(1-2):32-6
pubmed: 16777084
Diabetologia. 2001 Feb;44(2):129-46
pubmed: 11270668
J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):132-7
pubmed: 19182228
Int J Med Sci. 2014 Mar 13;11(5):453-60
pubmed: 24688308
Adv Pharmacol. 1992;23:1-34
pubmed: 1540533
Alcohol Alcohol. 2004 Jul-Aug;39(4):316-20
pubmed: 15208163
BMC Geriatr. 2018 Mar 27;18(1):80
pubmed: 29580209
Int J Angiol. 2014 Mar;23(1):11-6
pubmed: 24627612
Diabetologia. 2007 Jul;50(7):1409-17
pubmed: 17479244