Effect of Surgical Versus Medical Therapy on Diabetic Kidney Disease Over 5 Years in Severely Obese Adolescents With Type 2 Diabetes.

Adolescent Bariatric Surgery Blood Glucose / metabolism Child Diabetes Mellitus, Type 2 / blood Diabetic Nephropathies / blood Drug Therapy, Combination Female Follow-Up Studies Glomerular Filtration Rate Humans Hypoglycemic Agents / administration & dosage Life Style Male Metformin / administration & dosage Obesity, Morbid / blood Pediatric Obesity / blood Rosiglitazone / administration & dosage Treatment Outcome Weight Reduction Programs / methods

Journal

Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975

Informations de publication

Date de publication:
01 2020
Historique:
received: 09 04 2019
accepted: 30 09 2019
pubmed: 7 11 2019
medline: 26 9 2020
entrez: 6 11 2019
Statut: ppublish

Résumé

To compare diabetic kidney disease (DKD) rates over 5 years of follow-up in two cohorts of severely obese adolescents with type 2 diabetes (T2D) undergoing medical or surgical treatment for T2D. A secondary analysis was performed of data collected from obese participants of similar age and racial distribution enrolled in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) and the Treatment Options of Type 2 Diabetes in Adolescents and Youth (TODAY) studies. Teen-LABS participants underwent metabolic bariatric surgery (MBS). TODAY participants were randomized to metformin alone or in combination with rosiglitazone or intensive lifestyle intervention, with insulin therapy given for glycemic progression. Glycemic control, BMI, estimated glomerular filtration rate (eGFR), urinary albumin excretion (UAE), and prevalence of hyperfiltration (eGFR ≥135 mL/min/1.73 m Participants with T2D from Teen-LABS ( Compared with MBS, medical treatment of obese youth with T2D was associated with a higher odds of DKD over 5 years.

Identifiants

DOI: 10.2337/dc19-0708 PMID: 31685489 PMC: PMC6925577
pubmed: 31685489
pii: dc19-0708
doi: 10.2337/dc19-0708
pmc: PMC6925577
doi:

Substances chimiques

Blood Glucose 0
Hypoglycemic Agents 0
Rosiglitazone 05V02F2KDG
Metformin 9100L32L2N

Banques de données

ClinicalTrials.gov
['NCT00081328', 'NCT00474318']

Types de publication

Comparative Study Journal Article Multicenter Study Randomized Controlled Trial Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

187-195

Subventions

Organisme : NCRR NIH HHS
ID : UL1 RR025780
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061242
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024992
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119450
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061212
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR014467
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061230
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025758
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000084
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061254
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024139
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024989
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024153
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK072493
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000069
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000036
Pays : United States
Organisme : NIDDK NIH HHS
ID : UM1 DK095710
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR001066
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK116720
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000043
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL145076
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000125
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061239
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024134
Pays : United States

Informations de copyright

© 2019 by the American Diabetes Association.

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Auteurs

Petter Bjornstad (P)

University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO petter.bjornstad@childrenscolorado.org.
ORCID: 0000-0002-5160-2947

Kara Hughan (K)

University of Pittsburgh and UPMC Children's Hospital Pittsburgh, Pittsburgh, PA.

Megan M Kelsey (MM)

University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO.

Amy S Shah (AS)

University of Cincinnati, Cincinnati Children's Medical Center, Cincinnati, OH.

Jane Lynch (J)

The University of Texas Health Science Center at San Antonio, San Antonio, TX.

Edward Nehus (E)

University of Cincinnati, Cincinnati Children's Medical Center, Cincinnati, OH.

Mark Mitsnefes (M)

University of Cincinnati, Cincinnati Children's Medical Center, Cincinnati, OH.

Todd Jenkins (T)

University of Cincinnati, Cincinnati Children's Medical Center, Cincinnati, OH.

Peixin Xu (P)

University of Cincinnati, Cincinnati Children's Medical Center, Cincinnati, OH.

Changchun Xie (C)

University of Cincinnati, Cincinnati Children's Medical Center, Cincinnati, OH.

Thomas Inge (T)

University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO.
ORCID: 0000-0001-7782-1112

Kristen Nadeau (K)

University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Procédures de chirurgie opératoire › Chirurgie bariatrique › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Néphropathies diabétiques › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Débit de filtration glomérulaire › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Biguanides › Metformine › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Obésité morbide › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Obésité pédiatrique › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Thiazoles › Thiazolidinediones › Rosiglitazone › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Effect of Surgical Versus Medical Therapy on...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Services de médecine préventive › Éducation pour la santé › Promotion de la santé › Programmes de perte de poids › Effect of Surgical Versus Medical Therapy on...