RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization.

Animals Biomarkers Caspases / metabolism Cells, Cultured Collagen Corneal Injuries / chemically induced Corneal Neovascularization / enzymology Drug Combinations Enzyme Activation Fibroblast Growth Factor 2 / pharmacology GTPase-Activating Proteins / antagonists & inhibitors Human Umbilical Vein Endothelial Cells Humans Imidazoles / pharmacology In Situ Nick-End Labeling Indoles / pharmacology Laminin Lasers / adverse effects Macrophages / classification Mice Mice, Inbred C57BL Models, Animal Neovascularization, Pathologic / enzymology Oligopeptides / pharmacology Proteoglycans RNA, Messenger / biosynthesis Receptor-Interacting Protein Serine-Threonine Kinases / deficiency Receptors, Vascular Endothelial Growth Factor / therapeutic use Recombinant Fusion Proteins / pharmacology
AMD RIPK immune necrosis neovascular

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
19 11 2019
Historique:
pubmed: 7 11 2019
medline: 21 4 2020
entrez: 6 11 2019
Statut: ppublish

Résumé

Inflammation plays an important role in pathological angiogenesis. Receptor-interacting protein 1 (RIP1) is highly expressed in inflammatory cells and is known to play an important role in the regulation of apoptosis, necroptosis, and inflammation; however, a comprehensive description of its role in angiogenesis remains elusive. Here, we show that RIP1 is abundantly expressed in infiltrating macrophages during angiogenesis, and genetic or pharmacological inhibition of RIP1 kinase activity using kinase-inactive RIP1

Identifiants

DOI: 10.1073/pnas.1908355116 PMID: 31685620 PMC: PMC6876205
pubmed: 31685620
pii: 1908355116
doi: 10.1073/pnas.1908355116
pmc: PMC6876205
doi:

Substances chimiques

Biomarkers 0
Drug Combinations 0
GTPase-Activating Proteins 0
Imidazoles 0
Indoles 0
Laminin 0
Oligopeptides 0
Proteoglycans 0
RNA, Messenger 0
Ralbp1 protein, mouse 0
Recombinant Fusion Proteins 0
benzyloxycarbonyl-valyl-alanyl-aspartic acid 0
necrostatin-1 0
Fibroblast Growth Factor 2 103107-01-3
matrigel 119978-18-6
aflibercept 15C2VL427D
Collagen 9007-34-5
Receptors, Vascular Endothelial Growth Factor EC 2.7.10.1
Receptor-Interacting Protein Serine-Threonine Kinases EC 2.7.11.1
Ripk3 protein, mouse EC 2.7.11.1
Caspases EC 3.4.22.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

23705-23713

Subventions

Organisme : NEI NIH HHS
ID : R01 EY025362
Pays : United States
Organisme : NEI NIH HHS
ID : R21 EY023079
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY003790
Pays : United States

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Takashi Ueta (T)

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 113-8655 Tokyo, Japan.

Kenji Ishihara (K)

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.

Shoji Notomi (S)

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
ORCID: 0000-0002-7935-4244

Jong-Jer Lee (JJ)

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, 833 Kaohsiung, Taiwan.

Daniel E Maidana (DE)

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
ORCID: 0000-0002-3447-4074

Nikolaos E Efstathiou (NE)

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
ORCID: 0000-0002-6635-0391

Yusuke Murakami (Y)

Department of Ophthalmology, Graduate School of Medical Science, Kyushu University, 812-8582 Fukuoka, Japan.

Eiichi Hasegawa (E)

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.

Kunihiro Azuma (K)

Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 113-8655 Tokyo, Japan.

Tetsuya Toyono (T)

Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 113-8655 Tokyo, Japan.

Eleftherios I Paschalis (EI)

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
ORCID: 0000-0002-4544-4452

Makoto Aihara (M)

Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 113-8655 Tokyo, Japan.

Joan W Miller (JW)

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
ORCID: 0000-0003-2046-3996

Demetrios G Vavvas (DG)

Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114; demetrios_vavvas@meei.harvard.edu.
ORCID: 0000-0002-8622-6478

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Cellules › Cellules cultivées › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions traumatiques de la face › Lésions traumatiques de l'oeil › Lésions de la cornée › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Néovascularisation cornéenne › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Préparations pharmaceutiques › Association médicamenteuse › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Métabolisme › Activation enzymatique › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance fibroblastique › Facteur de croissance fibroblastique de type 2 › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Protéines d'activation de la GTPase › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Cellules endothéliales de la veine ombilicale humaine › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Méthode TUNEL › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Laminine › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures pour les applications des radiations › Lasers › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Protéoglycanes › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Receptor-Interacting Protein Serine-Threonine Kinases › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance endothéliale vasculaire › RIP1 kinase mediates angiogenesis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Protéines de fusion recombinantes › RIP1 kinase mediates angiogenesis by...