USP22 Interacts with PALB2 and Promotes Chemotherapy Resistance via Homologous Recombination of DNA Double-Strand Breaks.
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
17
01
2019
revised:
15
05
2019
accepted:
29
10
2019
pubmed:
7
11
2019
medline:
20
1
2021
entrez:
6
11
2019
Statut:
ppublish
Résumé
Homologous recombination (HR) is a highly conserved pathway that can facilitate the repair of DNA double-strand breaks (DSB). Several Deubiquitinases (DUB) have been implicated as key players in DNA damage repair (DDR) through HR. Here, we report USP22, a DUB that is highly overexpressed in multiple cancer types, is necessary for HR through a direct interaction with PALB2 through its C-terminal WD40 domain. This interaction stimulates USP22 catalytic activity
Identifiants
pubmed: 31685642
pii: 1541-7786.MCR-19-0053
doi: 10.1158/1541-7786.MCR-19-0053
pmc: PMC9285637
mid: NIHMS1541850
doi:
Substances chimiques
Fanconi Anemia Complementation Group N Protein
0
PALB2 protein, human
0
Ubiquitin Thiolesterase
EC 3.4.19.12
Usp22 protein, human
EC 3.4.19.12
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
424-435Subventions
Organisme : Doris Duke Charitable Foundation
ID : 2016105
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA197506
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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