Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock.
Animals
Cell Nucleus
/ metabolism
Circadian Clocks
Circadian Rhythm
Cyclin-Dependent Kinase 5
/ metabolism
Epistasis, Genetic
Mice
NIH 3T3 Cells
Period Circadian Proteins
/ chemistry
Phosphorylation
Phosphoserine
/ metabolism
Protein Stability
RNA, Small Interfering
/ metabolism
Saccharomyces cerevisiae
/ metabolism
Suprachiasmatic Nucleus
/ physiology
Time Factors
Cryptochrome 1
Period 2
S. cerevisiae
biochemistry
chemical biology
mouse
neuroscience
nuclear import
phosphorylation
proteasome
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
05 11 2019
05 11 2019
Historique:
received:
07
08
2019
accepted:
03
11
2019
pubmed:
7
11
2019
medline:
12
5
2020
entrez:
6
11
2019
Statut:
epublish
Résumé
Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. Here, we show that the cyclin-dependent kinase 5 (CDK5) regulates the mammalian circadian clock involving phosphorylation of PER2. Knock-down of
Identifiants
pubmed: 31687929
doi: 10.7554/eLife.50925
pii: 50925
pmc: PMC6890458
doi:
pii:
Substances chimiques
Per2 protein, mouse
0
Period Circadian Proteins
0
RNA, Small Interfering
0
Phosphoserine
17885-08-4
Cyclin-Dependent Kinase 5
EC 2.7.11.1
Banques de données
Dryad
['10.5061/dryad.j1fd7']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 31003A_166682
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 310030_166474/1
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 316030_177088
Pays : International
Organisme : Fondazione Cenci Bolognetti, Instituto Pasteur
ID : NA
Pays : International
Informations de copyright
© 2019, Brenna et al.
Déclaration de conflit d'intérêts
AB, IO, RC, JR, SL, ZH, CD, JD, UA No competing interests declared, EC Elisabetta Cameroni is affiliated with Humabs Biomed SA. The author has no other competing interests to declare.
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