Myeloid HMG-CoA Reductase Determines Adipose Tissue Inflammation, Insulin Resistance, and Hepatic Steatosis in Diet-Induced Obese Mice.

Adipose Tissue / drug effects Animals Blood Glucose Diet, High-Fat / adverse effects Fatty Liver / chemically induced Gene Expression Regulation, Enzymologic Hydroxymethylglutaryl CoA Reductases / genetics Inflammation / chemically induced Insulin / blood Insulin Resistance Macrophages Mice Mice, Knockout Myeloid Cells / metabolism Obesity / chemically induced

Journal

Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763

Informations de publication

Date de publication:
02 2020
Historique:
received: 23 01 2019
accepted: 28 10 2019
pubmed: 7 11 2019
medline: 3 7 2020
entrez: 7 11 2019
Statut: ppublish

Résumé

Adipose tissue macrophages (ATMs) are involved in the development of insulin resistance in obesity. We have recently shown that myeloid cell-specific reduction of HMG-CoA reductase (

Identifiants

DOI: 10.2337/db19-0076 PMID: 31690648
pubmed: 31690648
pii: db19-0076
doi: 10.2337/db19-0076
doi:

Substances chimiques

Blood Glucose 0
Insulin 0
Hydroxymethylglutaryl CoA Reductases EC 1.1.1.-
Hmgcr protein, mouse EC 1.1.1.34

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

158-164

Informations de copyright

© 2019 by the American Diabetes Association.

Auteurs

Akihito Takei (A)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Shuichi Nagashima (S)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Shoko Takei (S)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Daisuke Yamamuro (D)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Akiko Murakami (A)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Tetsuji Wakabayashi (T)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Masayo Isoda (M)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Hisataka Yamazaki (H)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Chihiro Ebihara (C)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Manabu Takahashi (M)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Ken Ebihara (K)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Shun Ishibashi (S)

Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan ishibash@jichi.ac.jp.
ORCID: 0000-0002-1063-1979

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Eucaryotes › Animaux › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes codant pour des enzymes › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › 3-Hydroxyacyl-CoA dehydrogenases › Hydroxymethylglutaryl-CoA reductases › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Myeloid HMG-CoA Reductase Determines Adipose...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Myeloid HMG-CoA Reductase Determines Adipose...