Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.
Acute Disease
Animals
Chemokines
/ metabolism
Cytokines
/ metabolism
Fibrinolysis
/ drug effects
Locomotion
/ physiology
Matrix Metalloproteinase 2
/ metabolism
Matrix Metalloproteinase 9
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Plasminogen
/ deficiency
Recovery of Function
/ drug effects
Spinal Cord
/ metabolism
Spinal Cord Injuries
/ metabolism
Tranexamic Acid
/ pharmacology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 11 2019
05 11 2019
Historique:
received:
24
04
2019
accepted:
21
10
2019
entrez:
7
11
2019
pubmed:
7
11
2019
medline:
4
11
2020
Statut:
epublish
Résumé
Spinal cord injury (SCI) is caused by an initial mechanical insult followed by a series of deleterious events that promote the progressive damage of affected tissues. Fibrinolysis, the process by which plasmin degrades cross-linked fibrin clots, has numerous functions in the central nervous system. However, the roles of the fibrinolytic system in SCI pathophysiology remain unknown. We investigated the roles of fibrinolysis in SCI, and explored therapeutic applications targeting fibrinolysis. Plasminogen-deficient (Plg
Identifiants
pubmed: 31690812
doi: 10.1038/s41598-019-52621-8
pii: 10.1038/s41598-019-52621-8
pmc: PMC6831600
doi:
Substances chimiques
Chemokines
0
Cytokines
0
Tranexamic Acid
6T84R30KC1
Plasminogen
9001-91-6
Matrix Metalloproteinase 2
EC 3.4.24.24
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16024Références
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